The Secretion and the Role of Insulin in Chick Embryos and Chickens

Leibson, L.; Бондарева, В. М.; Soltitskaya, Ljubov

doi:10.1016/b978-0-08-021257-9.50013-9

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…High levels of normal blood glucose in birds and insufficient insulin response to glucose by islets from 4-to 6-week-old chicks have been reported [19]. However, our blood glucose measurements in embryonic chicks up to 15 days after hatching [12], and previous studies on metabolic hormone profile in embryonic and posthatch chicks [42], have shown a gradual increase in blood glucose levels [9,43,44]. Therefore, we examined glucose response and function of B islets isolated from 5-6 day old chick pancreas [45].…”

Section: Usability Of Chick Pancreatic Islets To Screen For Insulin Scontrasting

confidence: 48%

Modeling Chick to Assess Diabetes Pathogenesis and Treatment

Datar¹,

Bhonde²

2011

Rev Diabet Stud

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■ AbstractAnimal models have been used extensively in diabetes research. Studies on animal models have contributed to the discovery and purification of insulin, development of new therapeutic approaches, and progress in fundamental and clinical research. However, conventional rodent and large animal mammalian models face ethical, practical, or technical limitations. Therefore, it would be beneficial developing an alternative model for diabetes research which would overcome these limitations. Amongst other vertebrates, birds are phylogenically closer to mammals, and amongst birds, the chick has been used as one of the favored models in developmental biology, toxicology, cancer research, immunology, and drug testing. Chicken eggs are readily available, have a short incubation period and easily accessible embryos. Based on these inimitable advantages, the present review article aims to discuss the suitability of the chick as a model system to study specific aspects of diabetes. The review focuses on the application of i) chick pancreatic islets for screening of antidiabetic agents and for islet banking, (ii) shell-less chick embryo culture as a model to study hyperglycemia-induced malformations observed in mammalian embryos, and (iii) chick chorioallantoic membrane (CAM) to examine glucose-induced endothelial damage leading to inhibition of angiogenesis.

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Section: Usability Of Chick Pancreatic Islets To Screen For Insulin Scontrasting

confidence: 48%

Modeling Chick to Assess Diabetes Pathogenesis and Treatment

Datar¹,

Bhonde²

2011

Rev Diabet Stud

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“…Our findings underscore the importance of a raised glucose level for the culture of embryonic avian insulin cells (and possibly other pancreatic endocrine cells) and suggest that the beneficial effects of Ham's F12, compared to Basal Medium Eagle, are in part due to the increased glucose content of the former medium. There is evidence that responsiveness to glucose for release of insulin occurs much earlier in chick embryos (Foltzer et al, 1982;Leibson et al, 1976; see also Epple and Brinn, 1987) than in rat foetuses (Hellerström and Swenne, 1991;Kervran and Randon, 1980). There is at present no information as to when chick insulin cells first respond to glucose by replicating but our data would suggest that this could occur during embryonic life when blood glucose levels are rising (Benzo and Green, 1974;Langslow, 1975;Simon and Leclercq, 1982).…”

Section: Effect Of Nutrientsmentioning

confidence: 52%