The secreted Ly-6/uPAR related protein-1 (SLURP1) stabilizes epithelial cell junctions and suppresses TNF-α-induced cytokine production

Conjunctival goblet cells: Ocular surface functions, disorders that affect them, and the potential for their regeneration

“…Large scale proteomics studies have identified hundreds of proteins in varying amounts within the tear fluid collected from healthy or diseased ocular surface, setting the stage for developing novel diagnostic markers and therapeutic targets for ocular surface pathologies [11][12][13][14][15][16] . Though powerful, these large-scale proteomics studies tend to miss small peptides such as SLURP1 that serves important immunomodulatory function in the ocular surface [17][18][19][20][21][22] . Additionally, tear biomarkers have been sought for systemic disorders such as Parkinson's disease 23 , Alzheimer's disease 24 and multiple sclerosis 25 .…”

To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2

“…Likewise, acute increases of adrenaline induced for example by exercise stress can mobilize innate immune-defense cells such as NK cells, non-classical monocytes and differentiated subsets of CD8 + T-cells ( Graff et al, 2018 ). Acute, short-term psychosocial stress can also mobilize endogenous factors such as secreted Ly-6/uPAR related protein-1 (SLURP1) that neutralize the infection-promoting effects of nicotine on its receptors by stabilizing barrier function and promoting T-cell activation ( Campbell et al, 2019 ; Peters et al, 2014 M; Razani-Boroujerdi et al, 2004 ; Tjiu et al, 2011 ). Finally, acute psychosocial stress leads to the rapid but transient release of neuropeptides such as SP from peripheral nerve endings in mucosae and skin, and this may contribute to first-line anti-viral defense by short-term upregulation of toll-like receptors (TLRs) ( Larsson et al, 2018 ; Yarmohammadi et al, 2021 ).…”

Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier

“…In this report, we further found that E. coli K1 infection promotes SLURP1, an endogenous a7 nAChR ligand secretion, and supplement of SLURP1 could greatly facilitate E. coli K1 dissemination into the CNS. These findings expand our knowledge of the pathogenesis process of E. coli K1 infection SLURP1 is a secreted protein that has structural homology with three-finger snake a-neurotoxins, acts in a both autocrine and paracrine manner, to activate a7 nAChR and thus exert potent anti-inflammatory activity (38)(39)(40)(41)(42)(43). Although the function of SLURP1 in modulated sterile inflammation has been extensively studied, its effects on the inflammation induced by microbial infection are largely unknown, especially on neuroinflammation.…”