2010
DOI: 10.1002/pmic.200900393
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The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini

Abstract: Infection with the human liver fluke, Opisthorchis viverrini, is a serious public health problem in Thailand, Laos and nearby locations in Southeast Asia. Both experimental and epidemiological evidence strongly implicate liver fluke infection in the etiology of one of the liver cancer subtypes, cholangiocarcinoma (CCA). To identify parasite proteins critical for liver fluke survival and the etiology of CCA, OFFGEL electrophoresis and Multiple reaction monitoring were employed to characterize 300 parasite prote… Show more

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Cited by 140 publications
(131 citation statements)
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“…hepatica (24,(63)(64)(65)(66), C. sinensis (67), and O. viverrini (68). Approximately 65% of the proteins identified here were also detected in at least one of these flukes, but only enolase, actin, and triose-phosphate isomerase were identified in all three species.…”
Section: Transcriptome and Secreted Proteome Of Fascioloides Magnamentioning
confidence: 85%
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“…hepatica (24,(63)(64)(65)(66), C. sinensis (67), and O. viverrini (68). Approximately 65% of the proteins identified here were also detected in at least one of these flukes, but only enolase, actin, and triose-phosphate isomerase were identified in all three species.…”
Section: Transcriptome and Secreted Proteome Of Fascioloides Magnamentioning
confidence: 85%
“…However, the protease profiles of both F. magna and Fa. hepatica (Fasciolidae) were markedly different from those of C. sinsensis and O. viverrini (Opisthorchiidae) (67,68), with only cathepsin B2 and legumain detected in the ES products of both families (Figs. 3C and 3D).…”
Section: Transcriptome and Secreted Proteome Of Fascioloides Magnamentioning
confidence: 99%
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“…In addition, classical excretorysecretory (ES) proteins of S. haematobium were predicted (on the basis of the presence of a signal peptide at the N terminus) using SignalP v.3.0 (ref. 40; using both the neural network and hidden Markov models) and the absence of a transmembrane domain using TMHMM 41 , and by BLASTp 42 homology-searching of the validated signal peptide database (SPD) 43 and an ES database containing published proteomic data for nematodes (Brugia malayi and Meloidogyne incognita) and trematodes (S. mansoni, S. japonicum, O. viverrini and F. hepatica) 13,14,[44][45][46][47][48][49][50] . The secondary structure of genes specific to S. haematobium were predicted using PSIPRED 51 .…”
Section: Methodsmentioning
confidence: 99%
“…Among these families, the TALs are of particular interest for schistosomiasis and other trematodiases. TAL homologues have been found in the tegument of Fasciola gigantica (Subpipattana et al, 2012;Vichasri-Grams et al, 2006), Fasciola hepatica (Banford et al;Orr et al, 2012), Opisthorchis viverrini (Mulvenna et al, 2010b) and Clonorchis sinensis (Chen et al, 2011;Huang et al, 2007;Kim et al, 2012;Zhou et al, 2007). The presence of TAL family members in the tegument of a variety of helminths suggests that these molecules are important for the host immune response to helminths.…”
Section: Schistosoma Mansoni Dlcs and Talsmentioning
confidence: 99%