The second step in resuscitation—the treatment of the ‘post-resuscitation’ disease

Part 9: Post–Cardiac Arrest Care

“…Most deaths occur during the first 24 hours after cardiac arrest. 5,6 The best hospital care for patients with ROSC after cardiac arrest is not completely known, but there is increasing interest in identifying and optimizing practices that are likely to improve outcomes (Table 1). 7 Positive associations have been noted between the likelihood of survival and the number of cardiac arrest cases treated at any individual hospital.…”

Post–Cardiac Arrest Syndrome

“…In the early 1970s, Dr Vladimir Negovsky recognized that the pathology caused by complete whole-body ischemia and reperfusion was unique in that it had a clearly definable cause, time course, and constellation of pathological processes. [1][2][3] Negovsky named this state "postresuscitation disease." Although appropriate at the time, the term "resuscitation" is now used more broadly to include treatment of various shock states in which circulation has not ceased.…”

“…Negovsky himself stated that a second, more complex phase of resuscitation begins when patients regain spontaneous circulation after cardiac arrest. 1 For these reasons, we propose a new term: "postcardiac arrest syndrome. "…”

How Can we Study Cardiopulmonary Resuscitation and Cardiac Arrest in Animals: a Review

“…This leads to a "post-cardiac arrest" syndrome which also includes systemic inflammatory response, coagulopathy and adrenal insufficiency [67,68]. In animal studies, this so-called "sepsis-like syndrome" can be evidenced by the evaluation of the cytokines transcription levels [53] and coagulation parameters [69], as well as numerous biomarkers for each particular organ.…”