The second brain in Parkinson’s disease: fact or fantasy?

Yemula, Nehal; Njoku, Paul; Takyi, Joseph

doi:10.4103/1673-5374.332144

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…In recent years, the effects of polyphenols on gut-brain axis and gut microorganisms have been discussed [87,88]. In general, it is accepted that gut microbiome modulation is a promising method for preventing neuroinflammations [89]. Nevertheless, the pathological processes involving Fe redox cycling cannot be neglected [23].…”

Section: Discussionmentioning

confidence: 99%

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

Kubicová

Bachmann

Weckwerth

et al. 2022

Cells

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Catechin is an extensively investigated plant flavan-3-ol with a beneficial impact on human health that is often associated with antioxidant activities and iron coordination complex formation. The aim of this study was to explore these properties with FeII and FeIII using a combination of nanoelectrospray-mass spectrometry, differential pulse voltammetry, site-specific deoxyribose degradation assay, FeII autoxidation assay, and brine shrimp mortality assay. Catechin primarily favored coordination complex formation with Fe ions of the stoichiometry catechin:Fe in the ratio of 1:1 or 2:1. In the detected Fe–catechin coordination complexes, FeII prevailed. Differential pulse voltammetry, the site-specific deoxyribose degradation, and FeII autoxidation assays proved that coordination complex formation affected catechin’s antioxidant effects. In situ formed Fe–catechin coordination complexes showed no toxic activities in the brine shrimp mortality assay. In summary, catechin has properties for the possible treatment of pathological processes associated with ageing and degeneration, such as Alzheimer’s and Parkinson’s diseases.

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Section: Discussionmentioning

confidence: 99%

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

Kubicová

Bachmann

Weckwerth

et al. 2022

Cells

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Exosomes for neurodegenerative diseases: diagnosis and targeted therapy

Tao,

Gao

2024

J Neurol

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Advances and Applications of Brain Organoids

Zeng

et al. 2023

Neurosci. Bull.

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Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an emerging model, the “brain organoid” integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain. In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors. Finally, we also discuss current limitations and the potential of brain organoids.

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The second brain in Parkinson’s disease: fact or fantasy?

Cited by 4 publications

References 12 publications

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

Exosomes for neurodegenerative diseases: diagnosis and targeted therapy

Advances and Applications of Brain Organoids

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