The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling

Abstract

Lipid signaling pathways define central mechanisms of cellular regulation. Productive lipid signaling requires an orchestrated coupling0020between lipid metabolism, lipid organization, and the action of protein machines that execute appropriate downstream reactions. Using membrane trafficking control as primary context, we explore the idea that the Sec14-protein superfamily defines a set of modules engineered for the sensing of specific aspects of lipid metabolism and subsequent transduction of ‘sensing’ information to a phosphoinositide-driven ‘execution phase’. In this manner, the Sec14–superfamily connects diverse territories of the lipid metabolome with phosphoinositide signaling in a productive ‘crosstalk’ between these two systems. Mechanisms of crosstalk, where non-enzymatic proteins integrate metabolic cues with the action of interfacial enzymes, represent unappreciated regulatory themes in lipid signaling.

Cellulose Synthesis and Cell Expansion Are Regulated by Different Mechanisms in Growing Arabidopsis Hypocotyls

“…It is not known whether any of these pathways are involved in the regulation of vesicle trafficking; however, they are good candidates to explore. Mechanisms linking cellular metabolic status to the regulation of vesicular secretion through Golgi-localized lipid binding SEC14 domain proteins have been proposed in animal cells (Bankaitis et al, 2010). Arabidopsis contains a family of these proteins and they are known to regulate vesicle trafficking (Huang et al, 2016).…”

Nitrate Reductase Knockout Uncouples Nitrate Transport from Nitrate Assimilation and Drives Repartitioning of Carbon Flux in a Model Pennate Diatom

“…In yeast and mammalian systems, PITPs, in addition to membrane lipid trafficking, function in lipid-mediated intracellular signaling and regulation of lipid metabolism (reviewed in Bankaitis et al, 2010;Cockcroft and Garner, 2013). (I) J33873 is also annotated as a PITP.…”

Phosphoinositide signaling in plant development

“…For instance, recent evidence in Arabidopsis indicates that Sec14-like lipid transfer proteins aid PI-protein interaction in a specific manner (Bankaitis et al, 2010;Ghosh et al, 2015;Schaaf et al, 2008;Vincent et al, 2005). As a consequence, membrane areas that contain Sec14-like proteins will exhibit potentiated PI effects, possibly similar to the effects of localized PI overproduction.…”