The search for new synthetic photosensitizers

Evaluation of the Intramolecular Charge-Transfer Properties in Solvatochromic and Electrochromic Zinc Octa(carbazolyl)phthalocyanines

“…Such transformations are very characteristic of formation of the phthalocyaninecentered cation-radical species, 63−66 which confirms that the first oxidation is indeed centered at the macrocycle. Following the well-defined literature on oxidation of the phthalocyanine systems, the near-infrared (NIR) band observed at 868 and 879 nm for [3] .+ and [4] .+ , respectively, can be assigned to the monomeric species, while transitions observed at 753 and 760 nm reflect some degree of aggregation within cation-radical species. 31 In general, the properties of phthalocyanines 3 and 4 with respect to aggregation is hindered by bulky carbazole and substituted carbazole groups and is proven by the aggregation experiment discussed above.…”

“…31 In general, the properties of phthalocyanines 3 and 4 with respect to aggregation is hindered by bulky carbazole and substituted carbazole groups and is proven by the aggregation experiment discussed above. Nevertheless, from the spectroelectrochemical data, it seems clear that aggregation in [3] .+ and [4] .+ species can be achieved. Reversibility of the phthalocyanine macrocycle oxidation was proven by reduction of the [3] .+ and [4] .+ species to the initial neutral phthalocyanines 3 and 4 under spectro-electrochemical conditions (Figure S36).…”

“…25−27 Structural modification of the Pc core can tune the ground-state absorption, changing the position of the most intense Q-band and the molar absorption coefficient. 4 This is considered a critical requirement for application of Pcs as photosensitizers in PDT and light-harvesting modules in solar cells.…”

The Synthesis and Singlet Oxygen Generation Study of 13(1)-N-Piperazinyl Chlorin e6-15(2),17(3)-Dimethyl Ester

“…[13] It is reasonable to expect that double photodynamic and possible antimicrobial action of this conjugate (13(1)-N-piperazinyl chlorin e 6 15(2),17(3)-dimethyl ester, 1), which is structurally similar to famous PC based on the chlorin e 6 trimethyl ester platform (2), may be useful for clinical application at PDT. [7,10] …”

“…[1] In particular, they are proven to be effective second generation photosensitizers (PC) for photodynamic therapy (PDT). [2][3][4][5][6][7][8][9][10] Taking into account numerous requirements for the medical utilization of PC, the chemical modification of the chlorophyll molecule should provide at least sufficient solubility in an aqueous-rich medium and simultaneously effective penetration through cell membranes. [2][3][4][5][6] The main reaction centers of Chl series are vinyl and ester groups, carbonyl function and the cyclopentanone ring.…”