This paper explores the main philosophical approaches of David Hilbert’s theory of proof. Specifically, it is focuses on his ideas regarding logic, the concept of proof, the axiomatic, the concept of truth, metamathematics, the a priori knowledge and the general nature of scientific knowledge. The aim is to show and characterize his epistemological approach on the foundation of knowledge, where logic appears as a guarantee of that foundation. Hilbert supposes that the propositional apriorism, proposed by him to support mathematics, sustains — on its turn — a general method for the treatment of the problem in other areas such as natural sciences. This method is axiomatic. Broadly speaking, we intend to recover and update the Hilbert’s philosophical thinking about the role of logic for scientific knowledge.