The Search for a Practical Approach to Emerging Diseases: The Case of Severe Acute Respiratory Syndrome (SARS)

Selmi, Carlo; Ansari, Aftab A.; Invernizzi, Pietro; Podda, Mauro; Gershwin, M. Eric

doi:10.1080/1044667031000137575

Cited by 3 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Keywords like coronavirus; COVID-19; medicinal plants; active principle; natural compounds; inhibitor; SARS; MERS or SARS-CoV-2; Spike protein; RAAS; Angiotensin-Converting-Enzyme Inhibitors (ACEi); Angiotensin Receptor Blocker (ARB) were used to carry out the search. In addition, studies published since 2002 were reviewed, as this was the year in which SARS was reported for the first time [ 73 ]. The common name of the studied plants was determined with the help of an expert botanist, using the references “Plantas Útiles de Litoral Ecuatoriano de Flor María Valverde Vadillo” [ 74 ] and the “Enciclopedia de las Plantas Útiles del Ecuador”, and the databases “Herbario Rapid Reference” ( ) Date accessed: 19 April 2019 and “Trópicos” ( ) Date accessed: 14 May 2019.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

et al. 2021

View full text Add to dashboard Cite

COVID-19 is a pandemic disease caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals. Disease management represents a challenge for many countries, given the shortage of medicines and hospital resources. The objective of this work was to review the medicinal plants, foods and natural products showing scientific evidence for host protection against various types of coronaviruses, with a focus on SARS-CoV-2. Natural products that mitigate the symptoms caused by various coronaviruses are also presented. Particular attention was placed on natural products that stabilize the Renin–Angiotensin–Aldosterone System (RAAS), which has been associated with the entry of the SARS-CoV-2 into human cells.

show abstract

Section: Methodsmentioning

confidence: 99%

“…A stressed organism is usually more predisposed to infections by microorganisms [ 73 ]. Frequent or very strong episodes of stress caused by an overactivated RAAS include an excessive conversion of Angiotensin I (AI) into Angiotensin II (AII) by the ACE [ 77 ].…”

Section: Pathogenesis Of Sars-cov-2mentioning

confidence: 99%

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The pas-sion for working in health care amplified as we witnessed across the globe the tragic events during 9/11 in New York City (Machado et al, 2022). Similarly, catastrophic events such as SARS-CoV-1 (Selmi et al, 2002) and devastating super typhoons such as Angela (The Joint Typhoon Warning Center, 1995) catalyzed powerful motivation to help people during and after a disaster or acute hospitalization.…”

Section: Twenty-five Years Ago When the Professional Casementioning

confidence: 99%

Reflections: Moving Forward and Ever Growing

Vergara

2024

Professional Case Management

View full text Add to dashboard Cite

Structural Biology of the Arterivirus nsp11 Endoribonucleases

Zhang

Deng

et al. 2017

J Virol

View full text Add to dashboard Cite

Endoribonuclease (NendoU) is unique and conserved as a major genetic marker in nidoviruses that infect vertebrate hosts. Arterivirus nonstructural protein 11 (nsp11) was shown to have NendoU activity and play essential roles in the viral life cycle. Here, we report three crystal structures of porcine reproductive and respiratory syndrome virus (PRRSV) and equine arteritis virus (EAV) nsp11 mutants. The structures of arterivirus nsp11 contain two conserved compact domains: the N-terminal domain (NTD) and C-terminal domain (CTD). The structures of PRRSV and EAV endoribonucleases are similar and conserved in the arterivirus, but they are greatly different from that of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoV), representing important human pathogens in the Nidovirales order. The catalytic center of NendoU activity is located in the CTD, where a positively charged groove is next to the key catalytic residues conserved in nidoviruses. Although the NTD is nearly identical, the catalytic region of the arterivirus nsp11 family proteins is remarkably flexible, and the oligomerization may be concentration dependent. In summary, our structures provide new insight into this key multifunctional NendoU family of proteins and lay a foundation for better understanding of the molecular mechanism and antiviral drug development.IMPORTANCE Porcine reproductive and respiratory syndrome virus (PRRSV) and equine arteritis virus are two major members of the arterivirus family. PRRSV, a leading swine pathogen, causes reproductive failure in breeding stock and respiratory tract illness in young pigs. Due to the lack of a suitable vaccine or effective drug treatment and the quick spread of these viruses, infected animals either die quickly or must be culled. PRRSV costs the swine industry around $644 million annually in the United States and almost €1.5 billion in Europe every year. To find a way to combat these viruses, we focused on the essential viral nonstructural protein 11 (nsp11). nsp11 is associated with multiple functions, such as RNA processing and suppression of the infected host innate immunity system. The three structures solved in this study provide new insight into the molecular mechanisms of this crucial protein family and will benefit the development of new treatments against these deadly viruses.

show abstract

The Search for a Practical Approach to Emerging Diseases: The Case of Severe Acute Respiratory Syndrome (SARS)

Abstract: The plague, which the Board of Health had feared might enter with the German troops into the Milanese, had entered it indeed, as is well known; and it is likewise well known, that it paused not here, but invaded and ravaged a great part of Italy. (A. Manzoni, The Bethrothed, 1826)

Cited by 3 publications

References 29 publications

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

Reflections: Moving Forward and Ever Growing

Structural Biology of the Arterivirus nsp11 Endoribonucleases

Contact Info

Product

Resources

About