The sea lamprey Petromyzon marinus genome reveals the early origin of several chemosensory receptor families in the vertebrate lineage

Libants, Scot; Carr, Kevin M.; Wu, Hong; Teeter, John H.; Chung-Davidson, Yu Wen; Zhang, Ziping; Wilkerson, C.; Li, Weiming

doi:10.1186/1471-2148-9-180

Cited by 59 publications

(65 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Borecký et al, 2001). The conserved gene synteny for Ucp (supplementary material Fig.S3) was partially observed in the sea lamprey draft genome 2.0 (Libants et al, 2009) and confirmed in draft genome 7.0 (Smith et al, 2013). In addition, a steroid 5α-reductase gene is inserted between the Elmod2 and Ucp2 genes (supplementary material Fig.S3), which has not been reported in other species (Borecký et al, 2001;Emre et al, 2007;Jastroch et al, 2005).…”

Section: The Journal Of Experimental Biology 216 (14)mentioning

confidence: 98%

“…Our extensive search in the sea lamprey draft genomes 2.0 (Libants et al, 2009) and7.0 (Smith et al, 2013) resulted in two homologs of UCP-2. This is consistent with the notion that UCP-2 may be the prototype of UCPs (Borecký et al, 2001;Emre et al, 2007;Jastroch et al, 2005).…”

Section: The Journal Of Experimental Biology 216 (14)mentioning

confidence: 99%

“…Necdin serves as an inhibitor in the process of mammalian brown adipogenesis (Seale et al, 2007). We searched for these markers in the sea lamprey draft genome 2.0 (Libants et al, 2009) and identified the full gene sequences and predicted the mRNA and protein sequences of these markers (supplementary material AppendixS1). RT-qPCR showed that PRDM16 was expressed at higher levels in rope tissue than in gill and muscle tissues (ANOVA, P=0.0005; Fisher's PLSD post hoc test: rope versus gill, P<0.005; rope versus muscle, P<0.0005; Fig.10A), suggesting that it may be driving adipogenesis in sea lamprey rope tissue.…”

Section: Transcriptional Control Of Rope Tissue Adipogenesismentioning

confidence: 99%

See 2 more Smart Citations

A thermogenic secondary sexual character in male sea lamprey

Chung-Davidson

Priess

Yeh

et al. 2013

Journal of Experimental Biology

Self Cite

View full text Add to dashboard Cite

SUMMARYSecondary sexual characters in animals are exaggerated ornaments or weapons for intrasexual competition. Unexpectedly, we found that a male secondary sexual character in sea lamprey (Petromyzon marinus) is a thermogenic adipose tissue that instantly increases its heat production during sexual encounters. This secondary sexual character, developed in front of the anterior dorsal fin of mature males, is a swollen dorsal ridge known as the 'rope' tissue. It contains nerve bundles, multivacuolar adipocytes and interstitial cells packed with small lipid droplets and mitochondria with dense and highly organized cristae. The fatty acid composition of the rope tissue is rich in unsaturated fatty acids. The cytochrome c oxidase activity is high but the ATP concentration is very low in the mitochondria of the rope tissue compared with those of the gill and muscle tissues. The rope tissue temperature immediately rose up to 0.3°C when the male encountered a conspecific. Mature males generated more heat in the rope and muscle tissues when presented with a mature female than when presented with a male (paired t-test, P<0.05). On average, the rope generated 0.027±0.013Wcm-3 more heat than the muscle in 10min. Transcriptome analyses revealed that genes involved in fat cell differentiation are upregulated whereas those involved in oxidative-phosphorylation-coupled ATP synthesis are downregulated in the rope tissue compared with the gill and muscle tissues. Sexually mature male sea lamprey possess the only known thermogenic secondary sexual character that shows differential heat generation toward individual conspecifics. Supplementary material available online at

show abstract

Section: The Journal Of Experimental Biology 216 (14)mentioning

confidence: 98%

Section: The Journal Of Experimental Biology 216 (14)mentioning

confidence: 99%

Section: Transcriptional Control Of Rope Tissue Adipogenesismentioning

confidence: 99%

See 1 more Smart Citation

A thermogenic secondary sexual character in male sea lamprey

Chung-Davidson

Priess

Yeh

et al. 2013

Journal of Experimental Biology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A standardized nomenclature system (TAAR) was proposed in 2005 based on a thorough examination of gene sequences, phylogenetic relationships, and chromosomal organization . This classification system has stood the test of time and been independently validated on numerous occasions (Hashiguchi and Nishida, 2007;Hussain et al, 2009;Libants et al, 2009;Vallender et al, 2010;Tessarolo et al, 2014;Azzouzi et al, 2015;Eyun et al, 2016;Gao et al, 2017). Indeed, the TAAR nomenclature system (Table 3) is now used exclusively by those active in the field.…”

Section: Trace Amine-associated Receptorsmentioning

confidence: 99%

“…At present, the majority of evidence suggests that an ancestral TAAR-like protein first emerged in lamprey (Gloriam et al, 2005;Hashiguchi and Nishida, 2007;Libants et al, 2009;Eyun et al, 2016), with a conserved TAAR signature motif appearing later, after the divergence of jawed vertebrates from jawless fish (Fig. 6).…”

Section: A Evolution Of Trace Amine-associated Receptorsmentioning

confidence: 99%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

264

287

View full text Add to dashboard Cite

Taste and odorant receptors of the coelacanth—A gene repertoire in transition

et al. 2013

View full text Add to dashboard Cite

G-protein coupled chemosensory receptors (GPCR-CRs) aid in the perception of odors and tastes in vertebrates. So far, six GPCR-CR families have been identified that are conserved in most vertebrate species. Phylogenetic analyses indicate differing evolutionary dynamics between teleost fish and tetrapods. The coelacanth Latimeria chalumnae belongs to the lobe-finned fishes, which represent a phylogenetic link between these two groups. We searched the genome of L. chalumnae for GPCR-CRs and found that coelacanth taste receptors are more similar to those in tetrapods than in teleost fish: two coelacanth T1R2s co-segregate with the tetrapod T1R2s that recognize sweet substances, and our phylogenetic analyses indicate that the teleost T1R2s are closer related to T1R1s (umami taste receptors) than to tetrapod T1R2s. Furthermore, coelacanths are the first fish with a large repertoire of bitter taste receptors (58 T2Rs). Considering current knowledge on feeding habits of coelacanths the question arises if perception of bitter taste is the only function of these receptors. Similar to teleost fish, coelacanths have a variety of olfactory receptors (ORs) necessary for perception of water-soluble substances. However, they also have seven genes in the two tetrapod OR subfamilies predicted to recognize airborne molecules. The two coelacanth vomeronasal receptor families are larger than those in teleost fish, and similar to tetrapods and form V1R and V2R monophyletic clades. This may point to an advanced development of the vomeronasal organ as reported for lungfish. Our results show that the intermediate position of Latimeria in the phylogeny is reflected in its GPCR-CR repertoire.

show abstract

The sea lamprey Petromyzon marinus genome reveals the early origin of several chemosensory receptor families in the vertebrate lineage

Cited by 59 publications

References 43 publications

A thermogenic secondary sexual character in male sea lamprey

A thermogenic secondary sexual character in male sea lamprey

Trace Amines and Their Receptors

Taste and odorant receptors of the coelacanth—A gene repertoire in transition

Contact Info

Product

Resources

About