The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants

Abstract

The stromal cell derived factor-1 (SDF-1) rs1801157 gene polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The current study was to precisely investigate the association between SDF-1 rs1801157 polymorphism and cancer risk using meta-analysis and the false positive report probability (FPRP) test. All 17,876 participants were included in the study. The meta-analysis results indicated a significant association between the SDF-1 rs1801157 polymorphism and cancer risk. By subgroup analyses, the results detected that the SDF-1 rs1801157 polymorphism was associated with cancer susceptibility among Asians and Caucasians. Additionally, we also found significant associations between the SDF-1 rs1801157 polymorphism and susceptibility to different types of cancer. However, to avoid a “false positive report”, we further investigated the significant associations observed in the present meta-analysis using the FPRP test. Interestingly, the results of the FPRP test indicated that only 4 gene models were truly associated with cancer risk, especially in Asians. Moreover, we confirmed that the SDF-1 rs1801157 gene polymorphism was only associated with lung and urologic cancer risk. In summary, this study suggested that the SDF-1 rs1801157 polymorphism may serve as a risk factor for cancer development among Asians, especially an increased risk of urologic and lung cancers.

Bladder Cancer Genetic Susceptibility. A Systematic Review

“…[ 21 ]. However, we excluded previous metaanalyses performed on variants in GSTM1 , NAT2 [ 2, 25–27 ], GSTP1 [ 25, 28 ], hOGG1 [ 29 ], NQO1 [ 25, 30–32 ], TP53 [ 33 ], XRCC1 [ 34–37 ], XRCC3 [ 25, 38 ], XPC [ 25 ], XPD [ 25 ], PSCA [ 32 ], SDF-1 [ 39 ], TRAIL-R1 [ 40 ], E-cadherin [ 41 ], and TGFBR1 [ 42 ].…”

The CXCL12 rs1801157 polymorphism and risk of colorectal cancer: a meta-analysis

“…For example, in an Asian population the polymorphism was associated with malignancies, but in a Caucasian population this was uncertain. 23 Xia et al found individuals with the A allele of the G801A polymorphism in the CXCL12 gene are under a higher risk for breast carcinoma. 35 Zhang et al demonstrated that SDF1 -3′A polymorphism may be associated with increased risk of hematological malignancy, especially for chronic myeloid leukemia, Hodgkin’s lymphoma, multiple myeloma and the non-Caucasian population.…”

“… 20 , 21 An increasing number of studies in recent years have confirmed an association between the CXCL12 rs1801157 polymorphism and the risk of malignancies. 22 , 23 Nevertheless, whether it is associated specifically with the risk of CRC remains controversial. Therefore, this meta-analysis of relevant studies was conducted to investigate further an association between CXCL12 rs1801157 polymorphism and the risk of CRC.…”

Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk

“…For examples, the significant association between SDF-1 rs1801157 polymorphism and hematological malignancy was observed by Zhang et al based on 9 related studies [ 23 ]. The related pooled analysis carried out by Tong et al suggested that SDF-1 rs1801157 polymorphism showed close association with cancer risk among Asians, especially influencing the susceptibility of urologic and lung cancers [ 24 ]. However, Wang et al found that there were no significant association between SDF-1 rs1801157 polymorphism and coronary hear disease based on 7 articles [ 25 ].…”