The SDF‐1/CXCR4 axis is involved in adipose‐derived stem cell migration
Jiang Li,
Tibin Deng,
Shaojie Zhu
et al.
Abstract:BackgroundIntravenous injection of adipose‐derived stem cells (ADSCs) can improve the urinary function of stress urinary incontinence (SUI) model rats and C‐X‐C chemokine receptor type 4 (CXCR4)‐positive ADSCs are found in urethral tissues. The CXCR4 ligand stromal cell‐derived factor‐1 (SDF‐1) is highly expressed in urinary incontinence model rats. In this study, we investigated the involvement of the SDF‐1/CXCR4 axis in the homing of ADSCs.MethodsADSCs were isolated from rats and purified. The levels of CXCR… Show more
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