The R eformatsky Reaction

Abstract

The reaction which takes place between a carbonyl compound such as an aldehyde, ketone, or an ester, and an alpha‐haloester in the presence of zinc is commonly known as the Reformatsky reaction. It represents an extension of the reactions of carbonyl compounds with a dialkylzinc or an alkylzinc halide, but possesses the advantage that the isolation of the organozinc compound is unnecessary. The process creates a new carbon‐carbon linkage and involves the following: Formation of an organozinc halide; addition to the carbonyl group of the aldehyde or ketone, decomposition by dilute acids.

Synthesis and Application of Nanocrystalline-Cellulose-Supported Acid Ionic Liquid Catalyst in Pechmann Reaction

“…It was clearly observed that the composite was in nanodimension size (about 48 nm). Chemically, coumarins can be synthesized by a range of methods such as the Perkin, Pechmann reaction, Knoevenagel condensation, Reformatsky, Wittig, and catalytic cyclization reactions [21][22][23][24][25][26][27][28][29]. Acid catalyzed Pechmann reaction is the simple and normally used method for synthesizing coumarins from activated phenols, mainly metasubstituted phenols containing nucleophilic substituent at meta-position.…”

Synthesis and antioxidant activity of novel 8-formyl-4-substitued coumarins

“…Coumarins have been synthesized by several methods including Pechmann [6], Perkin [7], Knoevenegal [8], Reformatsky [9] and Wittig reactions [10]. However, the Pechmann reaction is the most widely applied for the synthesis of coumarins due to simple reaction conditions and good yields.…”

Simple Synthesis of Some Novel Polyfunctionally Derivatives of 2H-Coumarin-2-One.

“…Coumarins were first synthesized via the Perkin reaction, and many simple coumarins are still prepared through this method, the Knoevemagel reaction emerged as an important synthetic method to synthesized coumarin derivatives with carboxyl group at the 3-position [12,13]. Many other synthetic methods for coumarins have been reported, including the Pechmann [14], Reformatsky [15] and Witting reactions [16]. The review is not exhaustive, it is intended to acquaint the reader with interesting group of synthetic organic compounds.…”