The ED₉₅ of Nalbuphine in Outpatient‐Induced Abortion Compared to Equivalent Sufentanil

Abstract

This prospective study evaluated the 95% effective dose (ED ) of nalbuphine in inhibiting body movement during outpatient-induced abortion and its clinical efficacy versus the equivalent of sufentanil. The study was divided into two parts. For the first part, voluntary first-trimester patients who needed induced abortions were recruited to measure the ED of nalbuphine in inhibiting body movement during induced abortion using the sequential method (the Dixon up-and-down method). In the second part, this was a double-blind, randomized study. Sixty cases of first-trimester patients were recruited and were randomly divided into two groups (n = 30), including group N (nalbuphine at the ED dose) and group S (sufentanil at an equivalent dose). Propofol was given to both groups as the sedative. The circulation, respiration and body movement of the two groups in surgery were observed. The amount of propofol, the awakening time, the time to leave the hospital and the analgesic effect were recorded. The ED of nalbuphine in inhibiting body movement during painless surgical abortion was 0.128 mg/kg (95% confidence intervals 0.098-0.483 mg/kg). Both nalbuphine and the equivalent dose of sufentanil provided a good intraoperative and post-operative analgesic effect in outpatient-induced abortion. However, the post-operative morbidity of dizziness for nalbuphine was less than for sufentanil (p < 0.05), and the awakening time and the time to leave the hospital were significantly shorter than those of sufentanil (p < 0.05). Nalbuphine at 0.128 mg/kg was used in outpatient-induced abortion as an intraoperative and post-operative analgesic and showed a better effect compared with sufentanil.

Comparison of ED95 of Butorphanol and Sufentanil for gastrointestinal endoscopy sedation: a randomized controlled trial

“…The primary outcome in this study was the recovery time, which represented the time from completion of the examination and to the patient's departure from the PACU. The standards for hospital discharge were our outpatient operational standards [14] (including vital signs, pain, orientation, dizziness, and walking). The secondary outcomes included the demographic and medical data, i.e., the incidence of respiratory depression (respiratory rate < 10 beats/min or SpO 2 < 90% in nasal catheter oxygenation with 3 L/min), the incidence of circulatory inhibition (MAP < 50 mmHg or HR < 45 beats /min), dosage of propofol, the incidence of failed sedation, fatigue severity scores (assessed with an 11point (0-10) scale [15] 15 min after awakening time), VAS score of abdominal pain (15 min after awakening time), value of hand grip strength before and 15 min after operation (assessed using an electronic hand dynamometer [EH101, Camry Co. Zhongshan, China]), the incidence of nausea and vomiting, and dizziness after awakening.…”

Comparison of ED95 of Butorphanol with Sufentanil for Gastrointestinal Endoscopy Sedation: a randomized controlled trial

“…Our primary outcome in this study was the recovery time that represented the time between completion of the examination and departure from the PACU). The standard of leaving the hospital is our outpatient operation standard [14] (including vital signs, pain, orientation, dizziness, and walking). Secondary outcomes included the demographic and medical data, including the incidence of respiratory depression (respiratory rate < 10 beats/min or SpO 2 < 90% in nasal catheter oxygenation with 3 L/min), the incidence of circulatory inhibition (MAP < 50 mmHg or HR < 45 beats /min), dosage of propofol, the incidence of failed sedation, fatigue severity scores were determined by binary regression (probit) [16].…”

Comparison of ED95 of Butorphanol and Sufentanil for Gastrointestinal Endoscopy Sedation: a Randomized Controlled Trial

“…The primary outcome in this study was the recovery time, which represented the time from completion of the examination and to the patient's departure from the PACU. The standards for hospital discharge were our outpatient operational standards [14] (including vital signs, pain, orientation, dizziness, and walking). The secondary outcomes included the demographic and medical data, i.e., the incidence of respiratory depression (respiratory rate < 10 beats/min or SpO 2 < 90% in nasal catheter oxygenation with 3 L/min), the incidence of circulatory inhibition (MAP < 50 mmHg or HR < 45 beats /min), dosage of propofol, the incidence of failed sedation, fatigue severity scores (assessed with an 11-point (0-10) scale [15] 15 min after awakening time ), VAS score of abdominal pain (15 min after awakening time), value of hand grip strength before and 15 min after operation ( assessed using an electronic hand dynamometer [EH101, Camry Co.…”