The <scp>ATA</scp> classification and <scp>TI‐RADS ACR</scp> predict not only benignity but also the histology of nonbenign tumors in thyroid nodules with indeterminate cytology

Rosário, Pedro Weslley; Silva, Alexandre Lemos; Calsolari, Maria Regina

doi:10.1002/dc.24650

Cited by 5 publications

(10 citation statements)

References 6 publications

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“…9,32 A thyroid nodule with high suspicion sonographic pattern is not only more frequently found to be cancer than a nodule with low suspicion sonographic pattern, but it is also more frequently found to be a papillary thyroid cancer. 9,32 Conversely, a follicular-pattern lesion is more likely found in nodules with low suspicion sonographic patterns. 9,32 This is the consequence of having derived high suspicion features from the analyses of a series in which most malignancies were papillary thyroid cancers.…”

Section: Institutional Rate Of Malignancy Of Each Category Of Sonogra...mentioning

confidence: 99%

“…9,32 Conversely, a follicular-pattern lesion is more likely found in nodules with low suspicion sonographic patterns. 9,32 This is the consequence of having derived high suspicion features from the analyses of a series in which most malignancies were papillary thyroid cancers. Thus, the genetic alterations found in cytologically indeterminate thyroid nodules are also expected to be different according to their sonographic features.…”

Section: Institutional Rate Of Malignancy Of Each Category Of Sonogra...mentioning

confidence: 99%

“…Also, a positive molecular test result on a highly suspicious nodule is unlikely to change management 31 . Furthermore, different degrees of suspicion also identify different types of tumours 9,32 . A thyroid nodule with high suspicion sonographic pattern is not only more frequently found to be cancer than a nodule with low suspicion sonographic pattern, but it is also more frequently found to be a papillary thyroid cancer 9,32 .…”

Section: Molecular Tests For the Evaluation Of Cytologically Indeterm...mentioning

confidence: 99%

“…Furthermore, different degrees of suspicion also identify different types of tumours 9,32 . A thyroid nodule with high suspicion sonographic pattern is not only more frequently found to be cancer than a nodule with low suspicion sonographic pattern, but it is also more frequently found to be a papillary thyroid cancer 9,32 . Conversely, a follicular‐pattern lesion is more likely found in nodules with low suspicion sonographic patterns 9,32 .…”

Section: Molecular Tests For the Evaluation Of Cytologically Indeterm...mentioning

confidence: 99%

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Clinical value of molecular markers as diagnostic and prognostic tools to guide treatment of thyroid cancer

Valderrábano

Eszlinger

Stewardson

et al. 2023

Clinical Endocrinology

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Objective Advances in our understanding of the molecular biology of thyroid tumours is being rapidly translated into their clinical management. This review summarizes the current use of molecular testing in thyroid tumours, focusing on their usefulness as diagnostic and prognostic tools to guide treatment with consideration of present limitations. Design Considerations about molecular testing applications for the diagnosis and treatment of thyroid tumours are divided into four sections/roles: (1) evaluating cytologically indeterminate thyroid nodules; (2) guiding extent of surgery in indeterminate thyroid nodules; (3) completing histological characterization of thyroid tumours and (4) identifying actionable mutations in advanced progressive thyroid cancers. Results Genomic testing can improve the presurgical malignancy risk assessment in indeterminate thyroid nodules. However, a prior in‐depth analysis of institutional quality and outcomes of sonographical, cytological and histological characterization of thyroid tumours is necessary. Presently, it remains uncertain whether knowing the molecular profile of a cytologically indeterminate thyroid nodule might be advantageous to modify the extent of initial surgery. Molecular characterization of thyroid tumours can be a valuable adjunct to morphological diagnosis in some challenging cases, such as in low‐risk follicular cell‐derived neoplasms, or rare tumours. Finally, as selective kinase inhibitors are available, molecular testing in locally advanced/metastatic progressive thyroid cancers should also be integrated into the institutional clinical management pathway to improve outcomes and limit toxicity. Conclusions Molecular testing needs to be implemented into the local evidence‐based clinical management thyroid nodule/cancer pathways to improve its diagnostic and prognostic value and to optimize cost‐effectiveness.

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Section: Institutional Rate Of Malignancy Of Each Category Of Sonogra...mentioning

confidence: 99%

Section: Institutional Rate Of Malignancy Of Each Category Of Sonogra...mentioning

confidence: 99%

Section: Molecular Tests For the Evaluation Of Cytologically Indeterm...mentioning

confidence: 99%

Section: Molecular Tests For the Evaluation Of Cytologically Indeterm...mentioning

confidence: 99%

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Clinical value of molecular markers as diagnostic and prognostic tools to guide treatment of thyroid cancer

Valderrábano

Eszlinger

Stewardson

et al. 2023

Clinical Endocrinology

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“…Only two Brazilian studies on this subject were found 15 , 16 . Neither of them finds relevant differences between ATA and ACR-TIRADS.…”

Section: Introductionmentioning

confidence: 99%

American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology: which one is better at predicting malignancy risk?

Andrade,

Costa,

Sousa

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The aim of this study was to compare the capacity of American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology in predicting malignancy risk of thyroid nodules and to verify which one is better at avoiding unnecessary fine needle aspiration. METHODS: This was a cross-sectional study with 565 thyroid nodules, followed at a tertiary care hospital, in an iodine-replete area. Those were classified as American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology systems and stratified according to the Bethesda classification of fine needle aspiration. The values of sensibility, specificity, positive predictive value, and negative predictive value accuracy were calculated. Also, the percentage of unnecessary biopsies was presented. RESULTS: The mean age of the individuals was 58.2±13.5 [26–90] years for benign nodules and 41.7±15.6 [23–66] years for malignant nodules (p=0.002). Regarding gender, 92.6% (n=150) of the individuals with benign nodules and 85.7% (n=06) with malignant nodules were females (p=0.601). For American Thyroid Association, 90.9% of sensibility, 51.4% of specificity, 52.6% of accuracy, 10.2% of positive predictive value, and 98.9% of negative predictive value were found. For Thyroid Imaging Reporting and Data System developed by the American College of Radiology, 90.9% of sensibility, 49.7% of specificity, 52.1% of accuracy, 9.9% of positive predictive value, and 98.9% of negative predictive value were found. .Notably, 12.3% of unnecessary fine needle aspiration were found in American Thyroid Association and 44.4% were found in Thyroid Imaging Reporting and Data System developed by the American College of Radiology. CONCLUSION: Both Thyroid Imaging Reporting and Data System developed by the American College of Radiology and American Thyroid Association are able to predict the malignancy risk of thyroid nodules. Thyroid Imaging Reporting and Data System developed by the American College of Radiology was better at avoiding unnecessary fine needle aspiration.

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The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules

Lin,

Cheng,

Zhang

et al. 2023

Endocrine

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The ATA classification and TI‐RADS ACR predict not only benignity but also the histology of nonbenign tumors in thyroid nodules with indeterminate cytology

Cited by 5 publications

References 6 publications

Clinical value of molecular markers as diagnostic and prognostic tools to guide treatment of thyroid cancer

Clinical value of molecular markers as diagnostic and prognostic tools to guide treatment of thyroid cancer

American Thyroid Association and Thyroid Imaging Reporting and Data System developed by the American College of Radiology: which one is better at predicting malignancy risk?

The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules

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