The Sclerotic Vertebral Body

Resnick, Donald

doi:10.1001/jama.1983.03330370071040

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…28 The vertebral column often exhibits a characteristic striped appearance (alternating bands of higher density along the end plates and decreasing density in the central portion of the vertebral body), also known as a rugger jersey spine. 41 Clinically, renal osteodystrophy expresses itself with diffuse and nonspecific bone pain and may be associated with weightbearing. It has not been confirmed whether this pain is a consequence of the microfractures within the structurally weaker bone.…”

Section: Renal Osteodystrophymentioning

confidence: 99%

Metabolic Bone Diseases in the Pediatric Population

Testini

Eusebi²,

Tupputi

et al. 2021

Semin Musculoskelet Radiol

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Bone plays an important role in regulating mineral balance in response to physiologic needs. In addition, bone is subject to a continuous remodeling process to maintain healthy bone mass and growth. Metabolic bone diseases are a heterogeneous group of diseases caused by abnormalities of bone mass, mineral structure homeostasis, bone turnover, or bone growth. In pediatrics, several significant advances have been made in recent years in the diagnosis of metabolic bone diseases (e.g., osteogenesis imperfecta, hyperparathyroidism, rickets, renal osteodystrophy, pediatric osteoporosis, and osteopetrosis). Imaging is fundamental in the diagnosis of these pathologies.

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Section: Renal Osteodystrophymentioning

confidence: 99%

Metabolic Bone Diseases in the Pediatric Population

Testini

Eusebi²,

Tupputi

et al. 2021

Semin Musculoskelet Radiol

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Imaging Findings of Metabolic Bone Disease

Chang¹,

Rosenthal

Mitchell³

et al. 2016

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Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth. Osteoporosis, the most common metabolic bone disease, results in generalized loss of bone mass and deterioration in the bone microarchitecture. Impaired chondrocyte development and failure to mineralize growth plate cartilage in rickets lead to widened growth plates and frayed metaphyses at sites of greatest growth. Osteomalacia is the result of impaired mineralization of newly formed osteoid, which leads to characteristic Looser zones. Hypophosphatasia is a congenital condition of impaired bone mineralization with wide phenotypic variability. Findings of hyperparathyroidism are the result of bone resorption, most often manifesting as subperiosteal resorption in the hand. Renal osteodystrophy is the collection of skeletal findings observed in patients with chronic renal failure and associated secondary hyperparathyroidism and can include osteopenia, osteosclerosis, and "rugger jersey spine." Hypoparathyroidism is most commonly due to iatrogenic injury, and radiographic findings of hypoparathyroidism reflect an overall increase in bone mass. Thyroid hormone regulates endochondral bone formation; and congenital hypothyroidism, when untreated, leads to delayed bone age and absent, irregular, or fragmented distal femoral and proximal tibial epiphyses. Soft-tissue proliferation of thyroid acropachy is most often observed in the hands and feet. The findings of acromegaly are due to excess growth hormone secretion and therefore proliferation of the bones and soft tissues. Vitamin C deficiency, or scurvy, impairs posttranslational collagen modification, leading to subperiosteal hemorrhage and fractures. RSNA, 2016.

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A case report of ivory vertebra sign: an initial radiological manifestation of underlying abdominal malignancy

Pothiawala

2022

Clin Exp Emerg Med

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Low back pain is one of the most common presenting complaints in the emergency department, and a plain radiograph of the lumbar spine is usually the first diagnostic modality. The ivory vertebra sign refers to the radiological appearance of a smooth, white ivory-like appearance of the affected single vertebra or multiple vertebral bodies. It is sometimes the initial radiologic manifestation of a variety of infectious, neoplastic, or metabolic diseases. Subsequent computerized tomography and magnetic resonance imaging are generally indicated to characterize the details, as well as look for other occult lesions. It is therefore important for emergency physicians to be aware of this, as this will aid in the appropriate evaluation and rapid diagnosis of the underlying disorder.

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The Sclerotic Vertebral Body

Cited by 3 publications

References 6 publications

Metabolic Bone Diseases in the Pediatric Population

Metabolic Bone Diseases in the Pediatric Population

Imaging Findings of Metabolic Bone Disease

A case report of ivory vertebra sign: an initial radiological manifestation of underlying abdominal malignancy

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