The scientific evidence for the role of milk protein-derived bioactive peptides in humans: A Review

Nongonierma, Alice B.; Fitzgerald, Richard J.

doi:10.1016/j.jff.2015.06.021

Cited by 199 publications

(131 citation statements)

References 176 publications

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“…Bioactive peptides from food-derived protein hydrolysates have been found to have positive effects on the major systems of the body such as the digestive, cardiovascular, nervous and immune systems [1,2]. Bioactive peptides have also been found to possess antioxidant capacity and their biological activity has been extensively studied [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Comparisons of Processing Stability and Antioxidant Activity of the Silkworm Pupae Protein Hydrolysates by Spray-dry and Freeze-dry

Shi

Lin

Xiao

et al. 2017

International Journal of Food Engineering

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Abstract:Silkworm pupae protein (SPP) was pretreated by different processing (heat/alkali/pepsin) and then hydrolyzed by five proteases (trypsin/flavorzyme/papain/protamex/alcalase), respectively. It was found that the combination of heat pretreatment and alkali pretreatment followed by enzymatic hydrolysis with trypsin and flavorzyme could remarkably improve the protein recovery. The hydrolysates obtained from silkworm pupae protein hydrolyzed with trypsin and flavorzyme were stable at the pH range of 4.0-8.0, remaining 95 % of its original reducing power and 90 % of its OH• scavenging activity. However, they were susceptible to alkaline treatments (pH > 10.0) and lost >30 % of their antioxidant activities. Pasteurization (65 °C × 30 min) or autoclaving sterilization (121 °C × 20 min) did not show notable effects on the antioxidant activities. It was concluded that silkworm pupae protein hydrolysates (SPPH) were better to be applied in either neutral or acidic food system rather than in alkaline conditions.

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Section: Introductionmentioning

confidence: 99%

Comparisons of Processing Stability and Antioxidant Activity of the Silkworm Pupae Protein Hydrolysates by Spray-dry and Freeze-dry

Shi

Lin

Xiao

et al. 2017

International Journal of Food Engineering

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“…In contrast to previously mentioned studies, results of studies that investigated levels of urinary opioid peptides in ASD were ambiguous [67,79,91,101]. One study found elevated levels of urinary exogenous opioids in autistic children [77,91]. In contrast, Cass et al, [102] and Hunter et al, [67] did not detect differences in urinary opioid peptide concentrations between ASD subjects and controls.…”

Section: Urinary Peptide Analysis In Asdmentioning

confidence: 85%

Section: Citation: Cieślińska a Kostyra E Savelkoul Hfj (2017) Treamentioning

confidence: 99%

“…In addition, there are also gluten-derived opioid peptides (exorphins like A4, A5, B4 and B537) that elicit similar effects in the brain through interaction with the δ-opioid receptor [76]. These dietary exorphins do bind with only low affinity for opioid receptors [77].Additionally, many other dietary proteins might contain amino acid sequences that exhibit antagonist activity on these opioid receptors. DPP4 is able to decrease opioid peptide levels in body fluids, including blood, urine and cerebrospinal fluid [65][66][67][68]78].…”

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confidence: 99%

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2015

HCIIN

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There is a rising interest in the use of dietary interventions to ameliorate prevalent brain diseases, including Autism Spectrum Disorder (ASD). Nowadays, the existence of communication between gut and brain is well accepted and thus diet can influence brain functioning. A well-known nutrition based intervention for ASD is the gluten-free and casein-free diet. However, only some of the patients experience a relief in symptoms and thus efficacy seems to be limited to certain phenotypes. However, not much is known about the mechanism of action through which this diet might work, or about interpersonal differences that could lead to variation in response to the diet. Current evidence for efficacy of the GFCF diet is poor. Large scale, good quality randomized controlled trials are needed. Genetic and environmentally induced interpersonal differences were found in intestinal membrane permeability and blood brain barrier integrity as well as in activity of peptidase enzymes. These differences probably affect responsiveness to the diet. In addition, age and duration of the dietary intervention play a role in the efficacy of the gluten-free and casein-free diet. This is the reason why all these factors need to be taken into account to give appropriate advice about whether or not to follow this diet.Keywords: Autism spectrum disorder; Casein-free; Casomorphin; Diet; Gluten-free; Intervention; Opioid; Peptides; Permeability Treating Autism Spectrum Disorder with Gluten-free and Casein-free Diet: The underlying Microbiota-Gut-Brain Axis MechanismsCitation: Cieślińska A, Kostyra E, Savelkoul HFJ (2017) Treating Autism Spectrum Disorder with • (GFCF) diet is strongly promoted while there are additional diets without salicylates and phenols, and anti-candida diets since many ASD patients are affected by this yeast [17]. However, so far it has been difficult to prove the effectiveness of this diet in all patients [10,18]. Limited information is available on the underlying mechanism as well as explanatory factors of differences in response to the GFCF diet. Here, we focus on the mechanism of action underlying this dietary intervention as well as the origin of differences in response to the GFCF diet. Gluten-Free and Casein-Free Diet Might Alleviate Autism Spectrum Disorder SymptomsPeople with ASD are often in need of intensive care and guidance, leading to loss of parental productivity and high emotional and economic costs [8,19]. Therefore it is important to investigate potential treatments that alleviate the symptoms or preferably cure the disease. So far, sometimes life long, educational and behavioral interventions are used, although these therapies have limited efficacy for ASD [6,20]. Currently, there is growing interest in nutritional interventions for this disorder and there are promising mechanisms underlying the putative success of such interventions [19].In 1983 it was suggested that gluten and casein containing products could cause autism-like symptoms by altering the functioning of the brain. It was propo...

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“…Despite numerous "in vitro" studies, further research is needed to clarify the relationship between the activity of BPs and their bioavailability. In this regard, the recent review by Nongonierma and FitzGerald, [52] summarizes the scientific evidence for the role of milk protein-derived BPs in humans and pointed out how double-blind randomized clinical trials based on the use of universal guidelines for the evaluation of BPs in humans are needed.…”

Section: Bioavailabilitymentioning

confidence: 99%

Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects

Lucarini¹

2017

Beverages

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Milk provides a wide range of biologically active compounds that protect humans against diseases and pathogens. The purpose of this work is to describe the main aspects and research lines concerning bioactive peptides: from their chemistry, bioavailability, and biochemical properties to their applications in the healthcare sector. In this context, the uses of bioactive peptides in nutraceutical and functional foods have been highlighted, also taking into account the perspective of innovative applications in the field of circular bioeconomy.Keywords: bioactive peptides; milk; nutraceuticals; bioavailability; biorefinery Bioactive Components of Milk: Focus on BPsMilk provides a wide range of biologically active compounds that protect humans against diseases and pathogens such as immunoglobulins, antimicrobial proteins and peptides, oligosaccharides, lipids, as well as many other components at low concentrations with significant potential health benefits [1] (Figure 1). Among these compounds, proteins play a key role as nutrients and as promoters of the physiological function and health role as source of Bioactive Peptides (BPs) [ Abstract: Milk provides a wide range of biologically active compounds that protect humans against diseases and pathogens. The purpose of this work is to describe the main aspects and research lines concerning bioactive peptides: from their chemistry, bioavailability, and biochemical properties to their applications in the healthcare sector. In this context, the uses of bioactive peptides in nutraceutical and functional foods have been highlighted, also taking into account the perspective of innovative applications in the field of circular bioeconomy.

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The scientific evidence for the role of milk protein-derived bioactive peptides in humans: A Review

Cited by 199 publications

References 176 publications

Comparisons of Processing Stability and Antioxidant Activity of the Silkworm Pupae Protein Hydrolysates by Spray-dry and Freeze-dry

Comparisons of Processing Stability and Antioxidant Activity of the Silkworm Pupae Protein Hydrolysates by Spray-dry and Freeze-dry

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Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects

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