The Science of Uncertainty and the Art of Probability

Elliott, Perry; McKenna, William J.

doi:10.1161/circulationaha.109.851287

Cited by 8 publications

(1 citation statement)

References 22 publications

(15 reference statements)

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“…Hypertrophic cardiomyopathy (HCM) is the most common inherited structural heart disease. It is one of the leading causes of sudden cardiac death (SCD) in young individuals and can lead to heart failure symptoms or death at any age (1,2). Although the European Society of Cardiology definition of HCM (3) is based on left ventricular (LV) wall thickness (≥15 mm in one or more myocardial segments that is not explained solely by loading conditions), right ventricular (RV) involvement in HCM is not uncom-mon (4).…”

Section: Introductionmentioning

confidence: 99%

Severe right ventricular hypertrophy in hypertrophic cardiomyopathy: Serious symptoms, complex surgical procedures, and poor prognosis in Fuwai Hospital

Dong¹,

Zhang²,

Qu³

et al. 2021

Anatolian J Cardiol

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Objective: Severe right ventricular hypertrophy (SRVH) in hypertrophic cardiomyopathy (HCM) is rare. We studied the clinical characteristics and prognosis of 36 patients with HCM and SRVH in a Chinese cohort. Methods: Patients with HCM and SRVH were enrolled between 2013 and 2017. The clinical characteristics, treatment therapies, and clinical outcomes of the 36 patients were retrospectively studied and compared with those of 128 patients without SRVH. Results: Patients in the group with SRVH were younger than those in the group without SRVH (27.58±15.09 years vs 40.34±13.21 years, respectively; p<0.001). Patients with SRVH had more serious clinical symptoms and a higher New York Heart Association functional class than those without SRVH. Most patients in the group with SRVH exhibited diffuse RV hypertrophy, and 13 patients presented with biventricular outflow tract obstruction. Maximal left ventricular (LV) wall thickness (27.29±7.95 mm vs 24.33±5.85 mm, respectively; p=0.027) and LV outflow tract gradient (80.83±24.41 mm Hg vs 42.3±5.7 mm Hg, respectively; p=0.000) were significantly greater in patients with SRVH than in those without SRVH. A total of 30 patients in the group with SRVH underwent surgical correction. During a median follow-up period of 48 months, six patients with SRVH reached primary clinical endpoints (four sudden cardiac deaths, one heart failure-related death, and one heart transplantation), whereas only two deaths occurred in the patients without SRVH. Conclusion:We conclude that patients with HCM and SRVH exhibit serious symptoms and have complex surgical requirements and poor clinical outcomes.

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Section: Introductionmentioning

confidence: 99%