The Science behind Biomaterials in Female Stress Urinary Incontinence Surgery

Amrute, Kaytan V.; Badlani, Gopal H.

doi:10.1100/tsw.2009.7

Cited by 7 publications

(10 citation statements)

References 57 publications

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“…These materials undergo extensive processing after harvesting to decellularize them and render them non-immunogenic. Additionally there are FDA regulations on animal source and vaccination status which must comply with [ 42 ]. Porcine dermis may be artificially cross-linked using hexamethylene diisocyanate to make it more resistant to enzymatic digestion [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

Gigliobianco

Román

Osman

et al. 2015

BioMed Research International

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Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical outcome are many, encompassing the physical and mechanical properties of the material used, and individual immune responses, as well surgical and constitutional factors. Of the current biomaterials in use none represents an ideal. Biomaterials that induce limited inflammatory response followed by constructive remodelling appear to have more long term success than biomaterials that induce chronic inflammation, fibrosis and encapsulation. In this review we draw upon published animal and human studies to characterize the changes biomaterials undergo after implantation and the typical host responses, placing these in the context of clinical outcomes.

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Section: Resultsmentioning

confidence: 99%

Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

Gigliobianco

Román

Osman

et al. 2015

BioMed Research International

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“…A stiff graft will have good mechanical strength, but will limit host response35 and lacks compliance in “molding” to the patient. On the other hand a flaccid graft may better conform to the patient's anatomy, but may lack the needed strength to correct SUI or POP 36…”

Section: The Use Of Biomaterials In Pop/suimentioning

confidence: 99%

Is tissue engineering and biomaterials the future for lower urinary tract dysfunction (LUTD)/pelvic organ prolapse (POP)?

Aboushwareb

McKenzie

Wezel

et al. 2011

Neurourology and Urodynamics

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The fields of tissue engineering and regenerative medicine have seen major advances over the span of the past two decades, with biomaterials playing a central role. Although the term "regenerative medicine" has been applied to encompass most fields of medicine, in fact urology has been one of the most progressive. Many urological applications have been investigated over the past decades, with the culmination of these technologies in the introduction of the first laboratory-produced organ to be placed in a human body.1 With the quality of life issues associated with urinary incontinence, there is a strong driver to identify and introduce new technologies and the potential exists for further major advancements from regenerative medicine approaches using biomaterials, cells or a combination of both. A central question is why use biomaterials? The answer rests on the need to make up for inadequate or lack of autologous tissue, to decrease morbidity and to improve long-term efficacy. Thus, the ideal biomaterial needs to meet the following criteria: (1) Provide mechanical and structural support, (2) Maintain compliance and be biocompatible with surrounding tissues, and (3) Be "fit for purpose" by meeting specific application needs ranging from static support to bioactive cell signaling. In essence, this represents a wide range of biomaterials with a spectrum of potential applications, from use as a supportive or bulking implant alone, to implanted biomaterials that promote integration and eventual replacement by infiltrating host cells, or scaffolds pre-seeded with cells prior to implant. In this review we shall discuss the structural versus the integrative uses of biomaterials by referring to two key areas in urology of (1) pelvic organ support for prolapse and stress urinary incontinence, and (2) bladder replacement/augmentation.

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“…18 For example, injectable microparticles as fillers and bulking agents have been developed to replace tissue volume loss in surgeries to treat stress-incontinence, lipoatrophy, and to induce lip augmentation. 19−22 Embolization microparticles were injected into a blood vessel to occlude tumor vasculature, leading to tumor ischemia and necrosis. 23,24 Also, fluorescent microparticles are used as tracking vehicles to study the dynamic distributions of micro-objects in tissues or vasculature.…”

Section: Introductionmentioning

confidence: 99%

Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance

Yang

Zhang

et al. 2019

ACS Cent. Sci.

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Injectable micron-sized particles have historically achieved promising applications, but they continued to suffer from long-term biofouling caused by the adhesions of biomolecules, cells, and bacteria. Recently, a slippery lubricant infusion porous substrate (SLIPS) exhibited robust antiadhesiveness against many liquids; however, they were constructed using a 2D substrate, and they were not suitable for in vivo applications, such as injectable biomaterials. Inspired by SLIPS, here, we report the first case of injectable solid microparticles coated with a lubricating liquid surface to continuously resist biofouling. In our design, microparticles were attached with nanospikes and fluorinated to entrap the lubricant. The nanospikes enabled the lubricant-coated spiky microparticles (LCSMPs) to anomalously disperse in water despite the attraction between the surfaces of the microparticles. This result indicated that the LCSMPs exhibited persistent anomalous dispersity in water while maintaining a robust lubricating surface layer. LCSMPs prevented the adhesion of proteins, mammalian cells, and bacteria, including Escherichia coli and Staphylococcus aureus . LCSMPs also reduced in vivo fibrosis while conventional microparticles were heavily biofouled. This technology introduced a new class of injectable anti-biofouling microparticles with reduced risks of inflammation and infections.

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The Science behind Biomaterials in Female Stress Urinary Incontinence Surgery

Cited by 7 publications

References 57 publications

Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

Biomaterials for Pelvic Floor Reconstructive Surgery: How Can We Do Better?

Is tissue engineering and biomaterials the future for lower urinary tract dysfunction (LUTD)/pelvic organ prolapse (POP)?

Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance

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