The Science and Translation of Lactate Shuttle Theory

Brooks, George A.

doi:10.1016/j.cmet.2018.03.008

Cited by 803 publications

(896 citation statements)

References 328 publications

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“…The increase in extracellular lactate concentration at the level of the colon could generate a change in the cells metabolism which implies a decrease in the rate of glycolysis that affects the normal activation of myeloid cells against proinflammatory stimuli (Iraporda et al . ; Brooks ).…”

Section: Metabolites Produced By Kefir Micro‐organismmentioning

confidence: 99%

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Iraporda²,

et al. 2018

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Kefir is a homemade viscous and slightly effervescent beverage obtained by milk fermentation with kefir grains, which are built up by a complex community of lactic acid and acetic acid bacteria and yeasts confined in a matrix of proteins and polysaccharides. The present review summarizes the role of kefir micro-organisms in grain assembly and in the beneficial properties attributed to kefir. The use of both culture-dependent and independent methods has made possible to determine the micro-organisms that constitute this ecosystem. Kefir consumption has been associated with a wide range of functional and probiotic properties that could be attributed to the micro-organisms present in kefir and/or to the metabolites synthetized by them during milk fermentation. In this context, the role of micro-organisms in kefir health promoting properties is discussed with particular attention to the contribution of yeast as well as bioactive metabolites such as lactic and acetic acid, exopolysaccharides and bioactive peptides. Even though many advances on the knowledge of this ancient fermented milk have been made, further studies are necessary to elucidate the complex nature of the kefir ecosystem.

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Section: Metabolites Produced By Kefir Micro‐organismmentioning

confidence: 99%

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Iraporda²,

et al. 2018

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“…Among these metabolic changes, blood acidosis has been identified in several in vitro and in vivo studies as a strong potential triggering factor for RBC sickling (Greenberg & Kass, ; Greenberg, Kass, & Castle, ; Lange, Minnich, & Moore, ). Given that muscle exercise is tightly linked to intra‐ and extracellular acidosis resulting from the non‐oxidative glycolytic processes of energy production (Bangsbo et al., ; Bangsbo, Johansen, Graham, & Saltin, ; Brooks, ; Ferguson et al., ; Hermansen & Osnes, ; Juel, ; Marcinek, Kushmerick, & Conley, ; Osnes & Hermansen, ; Sahlin, ; Sahlin, Alvestrand, Brandt, & Hultman, ; Sahlin, Harris, Nylind, & Hultman, ), one can wonder whether physical activity could be deleterious for SCD patients. To prevent the occurrence of any associated risks, extending our knowledge about the potential deleterious effects of muscle exercise in SCD patients is of great interest, particularly given that rehabilitation based on physical activity is increasingly considered as a potential therapeutic strategy in this pathology (Liem, Akinosun, Muntz, & Thompson, ; Martin et al., ).…”

Section: Sickle Cell Diseasementioning

confidence: 99%

“…It is now largely and commonly accepted that muscular exercise is associated with a significant intramuscular acidosis, even in aerobic conditions (Bendahan, Chatel, & Jue, ; Brooks, ). A variety of cellular processes can be activated in order to handle proton accumulation and the potential adverse effects (Juel, ).…”

Section: Can Exercise‐induced Acidosis Be Considered As a Triggering mentioning

confidence: 99%

Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Chatel

Messonnier

Bendahan

2018

Experimental Physiology

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Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder and the most common monogenic disease in the world. The root cause of this pathology is the synthesis of an abnormal Hb (HbS) that polymerizes in deoxygenated conditions, leading to the sickling of red blood cells. Acidosis is well recognized as a promoter of HbS polymerization and therefore red blood cell sickling. Indeed, it has been shown in vitro that the relative amount of sickled red blood cells increases markedly from 1% at pH 7.4 to >90% at pH 7.0. Nevertheless, no study has directly tested whether exercise-induced acidosis could favour SCD complications. Greater knowledge of the effects of metabolic acidosis during exercise could be of importance given the conclusions reached in several studies that proposed regular physical exercise as a therapeutic strategy in the management of SCD. In this review, we discuss the potential consequences of exercise-induced acidosis for the pathophysiology of SCD. We also propose some potential therapeutic interventions with the aim of reducing the metabolic acidosis related to exercise.

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“…It has been proposed that lactate can be shuttled around the body from the site of production to other tissues or non-exercising skeletal muscle [33]. We observed that blood lactate accumulation following the first uphill sprint was significantly lower than accumulations following the first SIT bout (Figure 3).…”

Section: Discussionmentioning

confidence: 67%

Early Adaptations to a Two-Week Uphill Run Sprint Interval Training and Cycle Sprint Interval Training

Kavaliauskas

Jakeman

Babraj

2018

Sports

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This study sought to compare early physiological and performance adaptations between a two-week cycle sprint interval training (SIT) and uphill run sprint training (UST) programs. Seventeen recreationally active adult males (age = 28 ± 5 years; body mass (BM) = 78 ± 9 kg) were assigned to either a control (n = 5), SIT (n = 6), or UST (n = 6) group. A discrete group of participants (n = 6, age = 33 ± 6 years, and body mass = 80 ± 9 kg) completed both training protocols to determine acute physiological responses. Intervention groups completed either a run or cycle peak oxygen uptake (VO2peak) test (intervention type dependent) prior to and following two weeks of training. Training comprised of three sessions per week of 4 × 30-s “all-out” sprints with a four-minute active recovery between bouts on a cycle ergometer against 7.5% of body mass in the SIT group and on a 10% slope in the UST group. The VO2peak values remained unchanged in both training groups, but time-to-exhaustion (TTE) was significantly increased only in the UST group (pre—495 ± 40 s, post—551 ± 15 s; p = 0.014) and not in the SIT group (pre—613 ± 130 s, post—634 ± 118 s, p = 0.07). Ventilatory threshold (VT) was significantly increased in both training groups (SIT group: pre—1.94 ± 0.45 L·min−1, post—2.23 ± 0.42 L·min−1; p < 0.005, UST group: pre—2.04 ± 0.40 L·min−1, post—2.33 ± 0.34 L·min−1, p < 0.005). These results indicate that UST may be an effective alternative to SIT in healthy individuals.

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The Science and Translation of Lactate Shuttle Theory

Cited by 803 publications

References 328 publications

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Early Adaptations to a Two-Week Uphill Run Sprint Interval Training and Cycle Sprint Interval Training

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