The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation

Ghorbani, Sarieh; Hoogewijs, Kurt; Pečenková, Tamara; Fernandez, Ana; Inzé, Annelies; Eeckhout, Dominique; Kawa, Dorota; Jaeger, Geert De; Beeckman, Tom; Madder, Annemieke; Breusegem, Frank Van; Hilson, Pierre

doi:10.1093/jxb/erw241

Cited by 54 publications

(72 citation statements)

References 43 publications

(79 reference statements)

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“…), they occasionally were shown to be required for peptide biogenesis (Ghorbani et al . ). We refer to such a cleavage event as the pre‐processing or, in cases where it is required in the maturation sequence, as the pre‐activation step.…”

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 95%

“…; Ghorbani et al . ), and even though these cleavages mark neither the N‐ nor the C‐terminus of the mature peptide (Fig. ), they occasionally were shown to be required for peptide biogenesis (Ghorbani et al .…”

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 99%

“…However, another study showed apoplastic localisation of S1P/AtSBT6.1 in complex with the serpin1 inhibitor (Ghorbani et al . ; Table ). The possibility that S1P/AtSBT6.1 exerts its function at multiple sites along the secretory pathway will have to be addressed in future studies.…”

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 99%

“…Regardless of their position considerably upstream of the mature peptide sequence, both sites were found to be important, the second site (RRAL) even essential, for RGF6 activity in vivo (Ghorbani et al . ). Cleavage by S1P/SBT6.1 is thus required as an obligatory step for pre‐activation, and additional protease(s) have to be postulated for the formation of the mature peptide.…”

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 99%

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Regulation of plant peptide hormones and growth factors by post‐translational modification

Stührwohldt

Schaller

2018

Plant Biol J

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The number, diversity and significance of peptides as regulators of cellular differentiation, growth, development and defence of plants has long been underestimated. Peptides have now emerged as an important class of signals for cell-to-cell communication over short distances, and also for long-range signalling. We refer to these signalling molecules as peptide growth factors and peptide hormones, respectively. As compared to remarkable progress with respect to the mechanisms of peptide perception and signal transduction, the biogenesis of signalling peptides is still in its infancy. This review focuses on the biogenesis and activity of small post-translationally modified peptides. These peptides are derived from inactive pre-pro-peptides of approximately 70-120 amino acids. Multiple post-translational modifications (PTMs) may be required for peptide maturation and activation, including proteolytic processing, tyrosine sulfation, proline hydroxylation and hydroxyproline glycosylation. While many of the enzymes responsible for these modifications have been identified, their impact on peptide activity and signalling is not fully understood. These PTMs may or may not be required for bioactivity, they may inactivate the peptide or modify its signalling specificity, they may affect peptide stability or targeting, or its binding affinity with the receptor. In the present review, we will first introduce the peptides that undergo PTMs and for which these PTMs were shown to be functionally relevant. We will then discuss the different types of PTMs and the impact they have on peptide activity and plant growth and development. We conclude with an outlook on the open questions that need to be addressed in future research.

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Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 95%

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 99%

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 99%

Section: Different Types Of Ptm and Their Relevance For Peptide Biogementioning

confidence: 99%

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Regulation of plant peptide hormones and growth factors by post‐translational modification

Stührwohldt

Schaller

2018

Plant Biol J

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“…Prediction of N-terminal signal peptides is done by specialized software programs, such as SignalP, which calculates the probability (D-value) that a given amino acid sequence comprises a signal peptide (Petersen et al, 2011). The proprotein resulting from signal peptide removal contains the final, bioactive peptide embedded within it, usually near the C terminus, which is released by endoproteolytic processing (Matsubayashi, 2014;Ghorbani et al, 2016;Schardon et al, 2016). A classification method for SSPs, based on the protein's amino acid sequence, has been proposed (Tavormina et al, 2015).…”

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confidence: 99%

Genome-Wide Identification of Medicago Peptides Involved in Macronutrient Responses and Nodulation

et al. 2017

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Growing evidence indicates that small, secreted peptides (SSPs) play critical roles in legume growth and development, yet the annotation of SSP-coding genes is far from complete. Systematic reannotation of the Medicago truncatula genome identified 1,970 homologs of established SSP gene families and an additional 2,455 genes that are potentially novel SSPs, previously unreported in the literature. The expression patterns of known and putative SSP genes based on 144 RNA sequencing data sets covering various stages of macronutrient deficiencies and symbiotic interactions with rhizobia and mycorrhiza were investigated. Focusing on those known or suspected to act via receptor-mediated signaling, 240 nutrient-responsive and 365 nodulation-responsive Signaling-SSPs were identified, greatly expanding the number of SSP gene families potentially involved in acclimation to nutrient deficiencies and nodulation. Synthetic peptide applications were shown to alter root growth and nodulation phenotypes, revealing additional regulators of legume nutrient acquisition. Our results constitute a powerful resource enabling further investigations of specific SSP functions via peptide treatment and reverse genetics.

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Small Post‐Translationally Modified Peptides – The Making Off

Stührwohldt

2022

Annual Plant Reviews Online

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Peptide hormones are an emerging new class of signalling molecules in plants, the importance of which has long been underestimated. One important class of peptides is the ‘small post‐translationally modified peptides’ (SPMPs), which require proteolytic processing as an essential step for maturation. SPMPs are derived from pre‐pro‐proteins that consist of 70 to 110 amino acids and harbour the mature peptides at, or close to their C‐termini. All SPMPs are subject to further post‐translational modifications during passage through the secretory pathway, including tyrosine sulphation and/or proline hydroxylation, which may be followed by O‐glycosylation. Despite the prevalence of hydroxyproline (Hyp) in SPMPs, the corresponding enzymes responsible for this post‐translational proline hydroxylation have not been identified, and it is unclear how the specificity of the proline targeted for hydroxylation is achieved. In this article, the current knowledge about the processing, biogenesis, compartmentalization, and post‐translational modifications of SPMPs will be discussed and analysed, and the open questions about the biogenesis of SPMPs will be pointed out.

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The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation

Abstract: HighlightMaturation of GLV signaling peptides requires two SBT6 subtilases. SBT6 proteolytic activity is further regulated by the Serpin1 inhibitor, implying a complex network that controls cell elongation in Arabidopsis.

Cited by 54 publications

References 43 publications

Regulation of plant peptide hormones and growth factors by post‐translational modification

Regulation of plant peptide hormones and growth factors by post‐translational modification

Genome-Wide Identification of Medicago Peptides Involved in Macronutrient Responses and Nodulation

Small Post‐Translationally Modified Peptides – The Making Off

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