The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception

Wang, Ping; Anderson, Neil W.; Pan, Yang; Poon, Leo L. M.; Charlton, Carmen; Zelyas, Nathan; Persing, David H.; Rhoads, Daniel D.; Babcock, Hilary M.

doi:10.1093/clinchem/hvaa080

Cited by 48 publications

(43 citation statements)

References 5 publications

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“…There is also no conclusive evidence that taking anti-inflammatory drugs is harmful for other respiratory infections [81]. [84,85]. Furthermore, the WHO announced a document regarding the laboratory biosafety guidance related to the 2019-nCoV.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Furthermore, the WHO announced a document regarding the laboratory biosafety guidance related to the 2019-nCoV. Healthcare providers and researchers must wear FFP3 or N95 masks and other protective gear when around COVID-19 patients [85]. For healthy people wearing a mask may not be the best way to prevent getting an infection.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

See 1 more Smart Citation

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

El-Aziz

Stockand

2020

Infection, Genetics and Evolution

302

300

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

El-Aziz

Stockand

2020

Infection, Genetics and Evolution

302

300

View full text Add to dashboard Cite

show abstract

“…The protocols of WHO network laboratories [5] facilitated the development of the rapid diagnosis of SARS-CoV-2 using nucleic acid amplification tests (NAATs), such as RT-PCR. However, the results of NAATs could be false negatives depending on the assay, specimen, and time course of the disease [6]. Public health testing capacity is likely to become overwhelmed in areas of widespread disease activity, and turnaround times are likely to be prolonged.…”

Section: Introductionmentioning

confidence: 99%

Utility of the neutrophil-to-lymphocyte ratio and C-reactive protein level for coronavirus disease 2019 (COVID-19)

Yan¹,

Liu²,

et al. 2020

Scandinavian Journal of Clinical and Laboratory Investigation

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To investigate the value of the combined detection of the neutrophil-to-lymphocyte ratio (NLR) and Creactive protein level (CRP) in the diagnosis of COVID-19. A total of 191 patients with COVID-19 were recruited at the Third Hospital of Wuhan from 21 January 2020 to 20 February 2020. Fifty healthy volunteers were randomly selected as the control group. Age, gender, white blood cell count (WBC), CRP, lymphocyte percentage, and NLR were extracted. Quantitative clinical characteristics and laboratory values were compared between groups. Risk factors and receiver operating characteristic (ROC) curves for COVID-19 were analyzed. We found that the NLR and CRP were higher, while the lymphocyte percentage was lower in patients with COVID-19 than in healthy controls. Among patients confirmed to have COVID-19, the NLR and CRP of the moderate group were lower than those of severely ill patients (severe, critical and death groups), and the lymphocyte percentage of the moderate group was higher than that of the critical and death group. There were no significant differences in WBC among all groups. Logistic regression analysis showed that the NLR, CRP, and lymphocyte percentage were independent risk factors for COVID-19. The AUC of the combined determination of NLR and CRP was 0.863, which was higher than that of NLR, CRP, WBC, and lymphocyte percentage (AUC: 0.835, 0.775, 0.416, and 0.749, respectively). Our results showed that the NLR and CRP were independent risk factors for COVID-19, and the combined detection of the NLR and CRP showed improved diagnostic performance for COVID-19.

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“… 19 Real-time PCR test which mainly makes use of a nasopharyngeal swab is still the confirmatory test. 20 , 21 Rapid testing and monitoring which is hot off the fire, detects IgM, IgA, IgG, or total antibodies, 19 and can be used by the dental practitioners for in-clinic screening of patients, with the results being available within a short span of time. 22 Of the many rapid test kits that have been developed recently, as on April 24, 2020, 45 have been approved by FDA 23 ( Fig.…”

Section: K Nowledge About Sars-cov-2 R Ementioning

confidence: 99%

Dentistry during and after COVID-19 Pandemic: Pediatric Considerations

Kochhar

Bhasin

Kochhar³

et al. 2020

International Journal of Clinical Pediatric Dentistry

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A bstract This article is a rumination on the outbreak of the dreaded coronavirus disease-2019 (COVID-19) pandemic which has engulfed both the developed and the developing countries, thereby causing widespread global public health concerns and threats to human lives. Although countries have made varied efforts, the pestilence is escalating due to the high infectivity. It is highly likely that dental professionals in upcoming days will come across COVID-19 patients and SARS-CoV-2 carriers, and hence must ensure a tactful handling of such patients to prevent its nosocomial spread. Despite the avalanche of information that has exploded in relation to this rapidly spreading disease, there is a lack of consolidated information to guide dentists regarding clinical management including precautions to take materials to use and postprocedure care, during and after the COVID-19 pandemic. Available sources of information have been analyzed, while relying on peer-reviewed reports followed by information available from the most respected authoritative sources, such as WHO, Centers for Disease Control and Prevention (CDC), and ADA. This review aims to provide a comprehensive summary from the available literature on COVID-19, its insinuation in dentistry, recommendations that have been published, and the actual in-practice implications, so a plan can be formulated and adapted to the circumstances of each dental practice during the pandemic and the times to follow. How to cite this article Kochhar AS, Bhasin R, Kochhar GK, et al . Dentistry during and after COVID-19 Pandemic: Pediatric Considerations. Int J Clin Pediatr Dent 2020;13(4):399–406.

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The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception

Cited by 48 publications

References 5 publications

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

Utility of the neutrophil-to-lymphocyte ratio and C-reactive protein level for coronavirus disease 2019 (COVID-19)

Dentistry during and after COVID-19 Pandemic: Pediatric Considerations

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