The Sarcoid-Lymphoma Syndrome

Goswami, Trishna; Siddique, Shahzad Khan; Cohen, Phillip; Cheson, Bruce D.

doi:10.3816/clml.2010.n.052

Cited by 32 publications

(32 citation statements)

References 48 publications

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“…In this context, the patient in the current study presented certain noteworthy characteristics as follows: i) The unusual presentation of NHL, which preceded sarcoidosis and was not treated with chemotherapy; ii) the long interval between the two diagnoses; iii) the particular type of NHL, a gastric MALT lymphoma that, to the best of our knowledge, was previously reported in <10 patients (2,18,19); and iv) the unusual presentation of sarcoidotic lesions, in particular, the hepatic and cutaneous manifestations (a psoriasis-like sarcoidosis pattern). These findings were not classically pathognomonic of sarcoidosis and complicated the differential diagnosis between other possible causes of granulomatous disorders (20,21).…”

Section: Discussionmentioning

confidence: 76%

“…In these rare cases, it was indicated that anticancer chemotherapy contributed to the worsening of the clinical manifestations of the underlying sarcoidosis (2). …”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, the first attempt to quantify the incidence of this phenomenon occurred in a retrospective study, which included 2,544 subjects presenting with sarcoidosis (2). Additional evidence that was obtained from retrospective clinical studies (3,4) and genetic linkage-analyses (5,6) focused on the association of sarcoidosis and malignancies and indicated a potential etiological correlation between the two clinical entities.…”

Section: Introductionmentioning

confidence: 99%

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Late-onset sarcoidosis in a patient with gastric mucosa-associated lymphoid tissue non-Hodgkin lymphoma: A case report

et al. 2014

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The simultaneous presence of hematological malignancies and sarcoidosis, defined as sarcoidosis-lymphoma syndrome, has been reported in 79 patients in the literature to date. The majority of these patients were affected by sarcoidosis and developed non-Hodgkin lymphoma or acute leukemia after 1–2 years; however, in <20 cases the malignancy developed first. This report presents the case of an 83-year-old male with a clinical history of Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue lymphoma. The patient developed sarcoidosis 10 years after the first diagnosis, which caused the diagnostic work-up and differential diagnosis between a lymphoma relapse and de novo sarcoidosis to be challenging.

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Section: Discussionmentioning

confidence: 76%

“…In these rare cases, it was indicated that anticancer chemotherapy contributed to the worsening of the clinical manifestations of the underlying sarcoidosis (2). …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Late-onset sarcoidosis in a patient with gastric mucosa-associated lymphoid tissue non-Hodgkin lymphoma: A case report

et al. 2014

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“…Isolated bone marrow sarcoidosis is exceedingly rare [4, 5]. The association between sarcoidosis and malignant disease including lymphoproliferative disorders has been previously explored [6, 7]. It has been postulated that chronic immune stimulation associated with chronic active sarcoidosis may lead to lymphoproliferative disorders, termed the “sarcoid-lymphoma syndrome” [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Hypercalcemia associated with isolated bone marrow sarcoidosis in a patient with underlying monoclonal gammopathy of undetermined significance: case report and review of literature

et al. 2016

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BackgroundBone marrow sarcoidosis is extremely rare. The association between sarcoidosis and lymphoproliferative disorders has been previously speculated, although the diagnosis of sarcoidosis often precedes any hematological derangements.Case presentationHere, we report for the first time, a case of a 57-year-old Caucasian woman with a previous diagnosis of monoclonal gammopathy of undetermined significance (MGUS) developing hypercalcemia and renal failure with workup notable for isolated bone marrow sarcoidosis and not multiple myeloma as expected. The patient was successfully managed with prednisone taper therapy with resolution of her hypercalcemia and repeat bone marrow biopsies demonstrating resolving granulomas.ConclusionsOur case illustrates the diagnostic challenges associated with bone marrow sarcoidosis and suggest that chronic immune stimulation in the bone marrow in the setting of MGUS may be associated with the development of localized sarcoidosis. The long term consequences of steroid therapy targeting sarcoidosis in this patient with underlying MGUS remain unknown. Greater surveillance and closer followup is planned in light of the increased risk of malignant transformation of MGUS into multiple myeloma in the setting of bone marrow sarcoidosis.

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“…The association between lymphoma and sarcoidosis was first suggested by Bichel and Brincker in the 1960s [6]. Since then, additional descriptions of this possible connection have been published but without providing a better understanding of this relationship [1].…”

Section: Introductionmentioning

confidence: 99%

Sarcoidosis-Lymphoma Syndrome: A Spectrum of One Disease

Sharquie¹,

Al-Hayani²,

Abdulwahhab³

et al. 2015

JCDSA

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Lymphoma might occur in association with sarcoidosis or sarcoidosis might be combined with lymphoma, in so called ("sarcoidosis-lymphoma syndrome"). This syndrome is well reported in medical literature. The question, which one starts before is difficult to answer, as in some cases sarcoidosis starts first then is followed by lymphoma but in other cases during the course of lymphoma sarcoid reaction might be seen. In the present report, we describe a case of 60 years male patient that is presented with a rash with classical sarcoid pathology that overtime changes into typical lymphoma ended with death.

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The Sarcoid-Lymphoma Syndrome

Cited by 32 publications

References 48 publications

Late-onset sarcoidosis in a patient with gastric mucosa-associated lymphoid tissue non-Hodgkin lymphoma: A case report

Late-onset sarcoidosis in a patient with gastric mucosa-associated lymphoid tissue non-Hodgkin lymphoma: A case report

Hypercalcemia associated with isolated bone marrow sarcoidosis in a patient with underlying monoclonal gammopathy of undetermined significance: case report and review of literature

Sarcoidosis-Lymphoma Syndrome: A Spectrum of One Disease

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