The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma?

Kosjerina, Zdravko; Zarić, Bojan; Vuckovic, Dejan; Lalosevic, Dusan; Djenadic, Goran; Murer, Bruno

doi:10.1186/2049-6958-7-11

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…Granulomatous inflammation is a hallmark in several infectious (e.g., mycobacterial) and noninfectious (e.g., sarcoidosis, Crohn's disease) diseases in response to persistent stimuli [5][6][7][8]. The central part of the granulomas usually consists of various macrophage populations and sparse multinucleated giant cells surrounded by a lymphatic cuff of T-and B-cells as well as fibroblasts, with mature granulomas also featuring a fibrotic layer [5,6,[9][10][11]. However, the architecture and immunology of granuloma formation differ significantly between granulomatous disorders [12].…”

Section: Introductionmentioning

confidence: 99%

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

Dievernich

Achenbach

Klinge

2021

Hernia

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Background Polypropylene (PP) mesh is widely used to reinforce tissues. The foreign body reaction (FBR) to the implant is dominated by innate immune cells, especially macrophages. However, considerable numbers of adaptive immune cells, namely T cells, have also been regularly observed, which appear to play a crucial role in the long-term host response. Methods This study investigated the FBR to seven human PP meshes, which were removed from the abdomen for recurrence after a median of one year. Using immunofluorescence microscopy, the FBR was examined for various innate (CD11b+ myeloid, CD68+ macrophages, CD56+ NK) and adaptive immune cells (CD3+ T, CD4+ T-helper, CD8+ cytotoxic, FoxP3+ T-regulatory, CD20+ B) as well as “conventional” immune cells (defined as cells expressing their specific immune cell marker without co-expressing CD68). Results T-helper cells (19%) and regulatory T-cells (25%) were present at comparable rates to macrophages, and clustered significantly toward the mesh fibers. For all cell types the lowest proportions of “conventional” cells (< 60%) were observed at the mesh–tissue interface, but increased considerably at about 50–100 µm, indicating reduced stimulation with rising distance to the mesh fibers. Conclusion Both innate and adaptive immune cells participate in the chronic FBR to PP meshes with T cells and macrophages being the predominant cell types, respectively. In concordance with the previous data, many cells presented a “hybrid” pattern near the mesh fibers. The complexity of the immune reaction seen within the foreign body granuloma may explain why approaches focusing on specific cell types have not been very successful in reducing the chronic FBR.

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Section: Introductionmentioning

confidence: 99%

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

Dievernich

Achenbach

Klinge

2021

Hernia

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“…A thorough clinical and histological trail must be done before arriving at a conclusion for granuloma. And also further research studies are needed to understand the cellular and molecular mechanisms of granuloma and its formation (Kosjerina et al, 2012). In this study 64% of the participants answered granuloma followed by 30% answered mouth ulcers.…”

Section: Resultsmentioning

confidence: 77%

Awareness on Oral Manifestation of Sarcoidosis Among Dental Students

Pathmashri.V.¹,

Ganapathy²,

Pandurangan³

et al. 2021

cibg

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The aim is to understand and create awareness about the oral manifestation of sarcoidosis among the dental students. Sarcoidosis is a common multisystemic granulomatous disease. Sarcoidosis is an inflammatory disease characterized by formation of non-necrotizing epithelioid granulomas. Granulomas are tiny clumps of inflammatory cells in one or more organs in our body. These can interfere with an organ's function and structure, if our immune system is over driven by these clumps of inflammatory cells. The commonly affected organ is lungs and in the head and neck its salivary glands. Oral manifestations of sarcoidosis are very rare and usually appear as non-tender swelling and ulcers in the lips, hard and soft palate, buccal mucosa, tongue and tonsils. The intraoral localized sarcoid lesion is histologically similar to a generalized sarcoidosis. No single test is enough for diagnosing and the presence of granuloma is also not enough to conclude the diagnosis. Oral manifestation of sarcoidosis is unusual, dentists must be aware that oral manifestation is specific localization and it is usually the first manifestation of the diseases. Therefore by knowing the oral manifestation of sarcoidosis, the dental students can be more aware of the prevalence of sarcoidosis and spread awareness among the patients.

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