The SAPHO syndrome

Kahn, Marcel-Francis; Khan, Muhammad Asim

doi:10.1016/s0950-3579(94)80022-7

Cited by 300 publications

(252 citation statements)

References 103 publications

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“…Over the years, SAPHO has been controversially adapted to encompass a spectrum of disorders sharing clinical and histological features, with more than 50 previously independent entities included under this umbrella term, [2] such as chronic recurrent multifocal osteomyelitis (CRMO), anterior chest wall syndrome and sternocostoclavicular hyperostosis. Despite the acronym, osteitis and hyperostosis constitute the hallmarks of SAPHO syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis can be made in the absence of cutaneous signs, which if they present, usually occur within 2 years from the onset of bone symptoms, although the interval may be in excess of 20 years. [3] The currently accepted diagnostic criteria for SAPHO syndrome is based on fulfilling at least one of the following parameters originally determined by Kahn et al in 1994: [2] 1) Multifocal osteitis with or without skin manifestations 2) Sterile acute or chronic joint inflammation associated with either pustules from psoriasis (usually palmoplantar) or severe acne (conglobata or fulminans)…”

Section: Discussionmentioning

confidence: 99%

“…It is of indeterminate aetiology, although some authors believe that an antigenic trigger, related to low grade Proprionobacterium acnes infection, may be contributory. [4] Others regard SAPHO to be an additional member of the seronegative spondyloarthropathies, [6,7] in view of common findings such as sacroiliitis and vertebral body involvement which occurs in about 50% of patients, [2,6] the higher prevalence of the HLA-B27…”

Section: Discussionmentioning

confidence: 99%

“…antigen (in 33%), [1,2,7] and the association with extra-articular manifestations such as inflammatory bowel disease, [8][9][10]13] enthesopathies, uveitis and psoriasis. [2,[7][8][9] CRMO, which is the commonest presentation of SAPHO syndrome, was found to affect 49% of patients in one cohort consisting of 173 SAPHO patients.…”

Section: Discussionmentioning

confidence: 99%

“…[2,[7][8][9] CRMO, which is the commonest presentation of SAPHO syndrome, was found to affect 49% of patients in one cohort consisting of 173 SAPHO patients. [13] CRMO is a clinicopathological diagnosis whereby sterile osteomyelitis (osteitis) is the key feature.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature

Siau

Laversuch

2009

Rheumatol Int

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International audienceSynovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare group of sterile, inflammatory osteoarticular disorders classically associated with skin lesions. It is occasionally associated with enteropathic disease such as ulcerative colitis. We present a 39-year-old patient with chronic ulcerative colitis who developed enteropathic SAPHO and responded well to pamidronate. We discuss the clinicopathological features with particular attention to bone pathology, and perform a literature review of this fascinating syndrome

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature

Siau

Laversuch

2009

Rheumatol Int

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Severe Cervicodynia in a Patient With Pustules on the Palms

Xia

2023

JAMA Neurol

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Propionibacterium acnes isolated from synovial tissue and fluid in a patient with oligoarthritis associated with acne and pustulosis

Schaeverbeke

Lequen

Barbeyrac³

et al. 1998

Arthritis & Rheumatism

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This report describes the case of a patient with a 14-month course of severe oligoarthritis associated with acne. Pure cultures of Propionibacterium acnes were isolated from synovial tissue and synovial fluid specimens collected from the same joint after a 4-month interval. After 2 months of treatment with roxithromy-cin 300 mglday, rifampicin 1,200 mglday, and a nonste-roidal antiinflammatory drug (NSAID), followed by 4 months of treatment with azithromycin 1 gm/week and an NSAID, the synovitis persisted. Cultures of skin lesions and synovial fluid at this time were negative. Although P acnes has previously been isolated from bone specimens obtained from patients with osteitis associated with acne, this is the first report of the isolation of this microorganism from the synovial tissue of a patient with arthritis associated with acne. Our findings raise the question of the role of P acnes in the pathogenesis of arthritis associated with acne. Acne is a chronic inflammatory disease of the pilosebaceous follicles, characterized by the formation of comedones and erythematous papules and pustules, and less frequently, by nodules or cysts and ulcerative lesions that can lead to definitive scarring. Acne can be differentiated into acne vulgaris (thc common form that begins classically in thc prepubertal period and resolves by the mid-20s; significant lesions can still bc sccn in 3%

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The SAPHO syndrome

Cited by 300 publications

References 103 publications

SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature

SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate: a case report and review of the literature

Severe Cervicodynia in a Patient With Pustules on the Palms

Propionibacterium acnes isolated from synovial tissue and fluid in a patient with oligoarthritis associated with acne and pustulosis

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