The Sandmeyer Reaction on Some Selected Heterocyclic Ring Systems: Synthesis of Useful 2-Chloroheterocyclic-3-carbonitrile Intermediates

Abstract

The Sandmeyer reaction on some selected heterocycles bearing the 2-amino-3-carbonitrile structural moiety has been investigated in order to prepare the corresponding 2-chloro-3-carbonitrile derivatives as synthetic useful intermediates for further development.

Recent trends in the chemistry of Sandmeyer reaction: a review

“…Da Silva et al [66] designed an effective approach for the synthesis of 2-chloro-3-carbonitrile analogs which are wellknown intermediates and can be transformed into a variety of useful and biologically important heterocyclic molecules, for example the highly polyfunctionalized 4H-pyran, oxazolo, pyrazolo, 1,4-dihydropyridine or pyridines derivatives. The authors used 2-amino-3-carbonitriles as starting precursors to obtain corresponding 2-chloro-3-carbonitriles via Sandmeyer approach.…”