The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population

Abstract

OBJECTIVERecent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GeneID Chinese Han population to 1) further replicate the association of 9p21.3 type 2 diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess the association of these SNPs with coronary artery disease.RESEARCH DESIGN AND METHODSThree SNPs (rs2383208, rs10811661, and rs10757283) were genotyped in two GeneID cohorts of 3,167 Chinese Han individuals. Case-control association design was used to determine the association of the SNPs with type 2 diabetes and coronary artery disease. Gensini scores were calculated in the coronary artery disease subjects and were tested for association with the variants. Multivariate logistic regressions were performed on association studies.RESULTSThe association between two of the three SNPs and type 2 diabetes was replicated in the GeneID population (rs2383208, P = 0.936; rs10811661-T, P = 0.02, odds ratio [OR] = 1.23; rs10757283-C, P = 0.003, OR = 1.30). The same two SNPs also contributed to the risk of coronary artery disease (CAD) (rs10811661-T, P = 0.002, OR = 1.19; rs10757283-C, P = 0.003, OR = 1.18). In addition, rs10757283 was associated with severity of coronary atherosclerosis estimated by the Gensini scoring system (risk allele C, quantitative-trait regression adjusted P = 0.002).CONCLUSIONSFor the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rs10811661 and rs10757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GeneID Chinese Han population.

SNP rs3825214 in TBX5 Is Associated with Lone Atrial Fibrillation in Chinese Han Population

“…We applied the criteria set by the American Diabetes Association to diagnose type 2 diabetes (T2DM) [17]. Evidence of coronary artery disease (CAD) was an angiograph showing more than 70% stenosis in at least one main vessel of the coronary artery.…”

Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications

“…Since large-vessel atherosclerosis can precede the development of diabetes (unlike classical microvascular complications), it had long been postulated that both conditions may share common genetic and environmental traits (dyslipidemia, hypertension), rather than atherosclerosis being a complication of diabetes [85]. A recent large-scale case-control study in a Chinese population was the first to report that two SNPs (rs10811661-T and rs10757283-C) on the 9p21.3 locus contribute to both the risk of T2D (OR 1.23 and 1.30, respectively) and CAD (OR 1.19-1.18, respectively) [86].…”

Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease

“…Notably, this locus is associated with both CHD and T2D in European ancestry individuals [5, 7–9] and also in Chinese Han individuals as shown in 2011 by Cheng et al . [6]. …”