The salt-inducible kinase KIN-29 regulates lifespan via the class II histone-deacetylase HDA-4

Nikooei, Tatiana; McDonagh, Aja; Linden, Alexander M. van der

doi:10.17912/micropub.biology.000289

Cited by 1 publication

(2 citation statements)

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Section: Histone Post-translational Modificationsmentioning

confidence: 99%

“…Similarly, mutation of Class II HDACs hda-10 ( Edwards et al, 2014 ) or hda-4 ( Edwards et al, 2014 ; Nikooei et al, 2020 ) have been shown to reduce WT lifespan in C. elegans . HDA-4 has also been shown to be required for the longevity of the kin-29(oy38) mutant ( Nikooei et al, 2020 ). KIN-29, a salt-inducible kinase, inhibits HDA-4 by phosphorylation ( van der Linden et al, 2007 ), suggesting that in WT worms and in the context of kin-29 mutants, HDA-4 activity may promote longevity.…”

Section: Histone Post-translational Modificationsmentioning

confidence: 99%

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Chromatin: the old and young of it

Emerson,

Lee

2023

Front. Mol. Biosci.

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Aging affects nearly all aspects of our cells, from our DNA to our proteins to how our cells handle stress and communicate with each other. Age-related chromatin changes are of particular interest because chromatin can dynamically respond to the cellular and organismal environment, and many modifications at chromatin are reversible. Changes at chromatin occur during aging, and evidence from model organisms suggests that chromatin factors could play a role in modulating the aging process itself, as altering proteins that work at chromatin often affect the lifespan of yeast, worms, flies, and mice. The field of chromatin and aging is rapidly expanding, and high-resolution genomics tools make it possible to survey the chromatin environment or track chromatin factors implicated in longevity with precision that was not previously possible. In this review, we discuss the state of chromatin and aging research. We include examples from yeast, Drosophila, mice, and humans, but we particularly focus on the commonly used aging model, the worm Caenorhabditis elegans, in which there are many examples of chromatin factors that modulate longevity. We include evidence of both age-related changes to chromatin and evidence of specific chromatin factors linked to longevity in core histones, nuclear architecture, chromatin remodeling, and histone modifications.

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