The salivary microbiome as a diagnostic biomarker of health and periodontitis: a large-scale meta-omics analysis before and after the removal of batch effects
Abstract:Background
Methodological differences in 16S rRNA sequencing studies have significant effects on the diversity of the results obtained, making comparisons in the form of traditional reviews controversial. This meta-omics study applies the best practices based on the available evidence and employs sequences from different Illumina V3-V4 bioprojects. The goal is to evaluate the salivary microbiota at the amplicon sequence variant (ASV) level in terms of differential proportionality and predictive models. This i… Show more
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