1983
DOI: 10.1177/00220345830620081501
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The Salivary Lactoperoxidase System in Caries-resistant and -susceptible Adults

Abstract: In a comparative study of caries-resistant and -susceptible adults, no significant differences were found in the concentrations of lactoperoxidase, thiocyanate, and pre-formed hypothiocyanite in parotid and submandibular saliva, or in hypothiocyanite formed in expectorated saliva over a 60-minute period. The concentrations per se of these components are not critical determinants of caries resistance or susceptibility. Thiocyanate concentration was higher in both unstimulated parotid and submandibular saliva th… Show more

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Cited by 29 publications
(15 citation statements)
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“…In human saliva, the levels of OSCN-range from 10 to 250 p.M (17,22,33,34,36) with an average of ca. 40 ,uM (34).…”
Section: Resultsmentioning
confidence: 99%
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“…In human saliva, the levels of OSCN-range from 10 to 250 p.M (17,22,33,34,36) with an average of ca. 40 ,uM (34).…”
Section: Resultsmentioning
confidence: 99%
“…Growing interest has recently been focused on innate, nonimmunoglobulin defense factors in the human mouth (14; I. D. Mandel and S. A. Ellison, in K. M. Pruitt and J. Tenovuo, ed., Chemistry and Biological Significance of the Lactoperoxidase System, in press) and on their possible association with dental caries (7,17) or periodontal diseases (12,13). However, because many innate (lysozyme, peroxidase, lactoferrin, agglutinins, etc.)…”
mentioning
confidence: 99%
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“…The HOSCN/OSCN generated in the mouth by oral per oxidase systems , or secreted from the major salivary glands Mandel et al, 1983] is an important, nonimmune defense factor for oral health [Tenovuo, 1991]. The HOSCN/OSCN is antimicro bial against a number of oral pathogens, such as mutans streptococci (including Streptococcus mutans) and lactobapH 7.6+0.2 pH 5.5±0.1 Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Saliva collected directly from the parotid and other salivaryglandscontains OSCN-, indicating that there isa source of H 202 within the glands and that SCN-is oxidized prior to secretion into the oral cavity (Pruitt et al, 1983;Mandel et al, 1987). Therefore, at least part of the OSCN-detected in mixed saliva is endogenous to saliva and not dependent on H 0 production by oral bacteria.…”
Section: Comparison Of Assay Methodsmentioning
confidence: 99%