The salivary gland epithelial cells of patients with primary Sjögren’s syndrome manifest significantly reduced responsiveness to 17β-estradiol

Manoussakis, Menelaos N.; Tsinti, Maria; Kapsogeorgou, Efstathia K.; Moutsopoulos, H. M.

doi:10.1016/j.jaut.2012.01.005

Cited by 26 publications

(9 citation statements)

References 35 publications

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“…In primary cultures of human SG cells, pre-treatment with 7β-estradiol impede IFNγ-induced upregulation of ICAM-1 in control group but not in pSS group. These data suggest a protective role of oestrogens on epithelial activation and the existence of a deficient estrogenic responsiveness in pSS [ 79 ]. Not surprisingly, the use of aromatase inhibitors in the treatment of breast cancer is associated with arthralgia or even authentic SS [ 80 , 81 , 82 ].…”

Section: Physiopathology Of Sjögren’s Syndromementioning

confidence: 99%

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Parisis

Chivasso

Perret

et al. 2020

JCM

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Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most frequent connective tissue disease after rheumatoid arthritis, affecting 0.3–3% of the population. Women are more prone to develop pSS than men, with a sex ratio of 9:1. Considered in the past as innocent collateral passive victims of autoimmunity, the epithelial cells of the salivary glands are now known to play an active role in the pathogenesis of the disease. The aetiology of the “autoimmune epithelitis” still remains unknown, but certainly involves genetic, environmental and hormonal factors. Later during the disease evolution, the subsequent chronic activation of B cells can lead to the development of systemic manifestations or non-Hodgkin’s lymphoma. The aim of the present comprehensive review is to provide the current state of knowledge on pSS. The review addresses the clinical manifestations and complications of the disease, the diagnostic workup, the pathogenic mechanisms and the therapeutic approaches.

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Section: Physiopathology Of Sjögren’s Syndromementioning

confidence: 99%

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Parisis

Chivasso

Perret

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…In support of this idea, low salivary estrogen levels have been found to correlate with a feeling of dry mouth in healthy menopausal women [ 72 ] and low circulating estrogen levels with ocular dryness in SS patients [ 73 ]. Salivary gland epithelial cells express ERα and ERβ, and these cells from SS patients have been found to have reduced responsiveness to estrogen (i.e., 17β-estradiol) [ 74 , 75 ], a factor that may be linked to the menopausal transition. Additionally, aromatase deficient mice, which should prevent the conversion of androgens to estrogen resulting in lower estrogen, develop a SS-like disease with increased inflammation of exocrine glands [ 76 ].…”

Section: Reviewmentioning

confidence: 99%

Sex differences in Sjögren’s syndrome: a comprehensive review of immune mechanisms

et al. 2015

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Autoimmune diseases (ADs) are estimated to affect between 5 and 8 % of the US population, and approximately 80 % of these patients are women. Sjögren’s syndrome (SS) is an AD that occurs predominately in women over men (16:1). The hallmark characteristic of SS is diminished secretory production from the primary exocrine gland and the lacrimal or salivary glands resulting in symptoms of dry eye and mouth. The disease is believed to be mediated by an inflammatory and autoantibody response directed against salivary and lacrimal gland tissues. This review will examine the literature on sex differences in the immune response of patients and animal models of Sjögren’s syndrome in order to gain a better understanding of disease pathogenesis.

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“…In addition, it can inhibit innate Toll-like receptor (TLR) responses and reduce IFNγ production in immune cells [38,143]. Furthermore, estrogens can protect the disease progression of SS by reducing SS-related proinflammatory responses, such as IL-17, IFNγ, and autoantibodies Ro/SSA and La/SSB [20,82,[144][145][146][147][148]216].…”

Section: Sjögren's Syndrome 231 Effect Of Sex Hormones On Inflammatory Response In Sjögren's Syndromementioning

confidence: 99%

Sex Differences in Otolaryngology: Focus on the Emerging Role of Estrogens in Inflammatory and Pro-Resolving Responses

Luo

Chiu

Chen

et al. 2021

IJMS

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Otolaryngology (also known as ear, nose, and throat (ENT)) diseases can be significantly affected by the level of sex hormones, which indicates that sex differences affect the manifestation, pathophysiology, and outcomes of these diseases. Recently, increasing evidence has suggested that proinflammatory responses in ENT diseases are linked to the level of sex hormones. The sex hormone receptors are present on a wide variety of immune cells; therefore, it is evident that they play crucial roles in regulating the immune system and hence affect the disease progression of ENT diseases. In this review, we focus on how sex hormones, particularly estrogens, regulate ENT diseases, such as chronic rhinosinusitis, vocal fold polyps, thyroid cancer, Sjögren’s syndrome, and head and neck cancers, from the perspectives of inflammatory responses and specialized proresolving mediator-driven resolution. This paper aims to clarify why considering sex differences in the field of basic and medical research on otolaryngology is a key component to successful therapy for both males and females in the future.

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The salivary gland epithelial cells of patients with primary Sjögren’s syndrome manifest significantly reduced responsiveness to 17β-estradiol

Cited by 26 publications

References 35 publications

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

Sex differences in Sjögren’s syndrome: a comprehensive review of immune mechanisms

Sex Differences in Otolaryngology: Focus on the Emerging Role of Estrogens in Inflammatory and Pro-Resolving Responses

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