The safety of radiofrequency thermal ablation in the treatment of liver malignancies

Casaril, Andrea; Hilal, Mohammed Abu; Harb, Ayad; Campagnaro, Tommaso; Mansueto, Giancarlo; Nicoli, N

doi:10.1016/j.ejso.2007.05.003

Cited by 14 publications

(14 citation statements)

References 24 publications

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“…Therefore, early diagnosed or unresectable HCC have indication to locoregional and thus less invasive treatments instead of hepatic surgery, which, albeit mini-invasive, can precipitate a cirrhotic patient into a condition of hepatic failure. Among less invasive treatments, although not free of complications, ultrasonography guided percutaneous radiofrequency ablation (RFA) has recently gained increasing consensus to approach HCC patients at early stage by showing safety and efficiency with minimal destruction of parenchyma [7]. In some patients, transarterial chemoembolization (TACE) still represents a valid alternative to surgery [8].…”

Section: Introductionmentioning

confidence: 99%

Liver Function as Assessed by Breath Tests in Patients With Hepatocellular Carcinoma

Palmieri¹,

Grattagliano²,

Minerva³

et al. 2009

Journal of Surgical Research

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Section: Introductionmentioning

confidence: 99%

Liver Function as Assessed by Breath Tests in Patients With Hepatocellular Carcinoma

Palmieri¹,

Grattagliano²,

Minerva³

et al. 2009

Journal of Surgical Research

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“…where q was previously defined as the tissue density (kg=m 3 ), C is the specific heat of tissue (J=kg= C), t is the elapsed time, k is the thermal conductivity of tissue (W=m= C), W b is the blood perfusion rate (kg=m 3 =s), C b is the specific heat of blood (J=kg= C) (assumed equal to C in this paper), T a is the arterial blood temperature (assumed to be 37 C), Q p is the power deposition per unit volume (W=m 3 ), and @T=@t denotes the partial derivative of the temperature with respect to time. For a plane wave, the power deposition Q p can be defined as, 38 …”

Section: Iic Thermal Modelmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13] Noninvasive thermal ablation may enhance the efficacy of ionizing radiation therapy and chemotherapy, and potentially reduce the need for surgery, and thus it has the potential to provide significant outcome improvements and lower morbidity rates in this and other high-risk patient populations. 6,[14][15][16] The SonoKnife, a new concept for a noninvasive (externally applied), scan-able, high intensity linefocused ultrasound thermal therapy system, was conceived for thermal ablation of advanced (persistent or recurrent) superficial head and neck tumors and positive lymph nodes that are located not more than 5 cm from the skin and are not larger than 3 cm in diameter.…”

Section: Introductionmentioning

confidence: 99%

SonoKnife: Feasibility of a line‐focused ultrasound device for thermal ablation therapy

et al. 2011

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Purpose: To evaluate the feasibility of line-focused ultrasound for thermal ablation of superficially located tumors. Methods: A SonoKnife is a cylindrical-section ultrasound transducer designed to radiate from its concave surface. This geometry generates a line-focus or acoustic edge. The motivation for this approach was the noninvasive thermal ablation of advanced head and neck tumors and positive neck nodes in reasonable treatment times. Line-focusing may offer advantages over the common point-focusing of spherically curved radiators such as faster coverage of a target volume by scanning of the acoustic edge. In this paper, The authors report studies using numerical models and phantom and ex vivo experiments using a SonoKnife prototype. Results: Acoustic edges were generated by cylindrical-section single-element ultrasound transducers numerically, and by the prototype experimentally. Numerically, simulations were performed to characterize the acoustic edge for basic design parameters: transducer dimensions, line-focus depth, frequency, and coupling thickness. The dimensions of the acoustic edge as a function of these parameters were determined. In addition, a step-scanning simulation produced a large thermal lesion in a reasonable treatment time. Experimentally, pressure distributions measured in degassed water agreed well with acoustic simulations, and sonication experiments in gel phantoms and ex vivo porcine liver samples produced lesions similar to those predicted with acoustic and thermal models. Conclusions: Results support the feasibility of noninvasive thermal ablation with a SonoKnife.

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“…Therefore, establishing and maintaining control of the intrahepatic disease remains the biggest problem for all RICC patients. [9][10][11] . RFA has low morbidity and mortality rates, and can effectively destroy tumor and preserve the maximal normal liver parenchyma as a local treatment for hepatic tumors, which has been confirmed by many clinical studies [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] . RFA has low morbidity and mortality rates, and can effectively destroy tumor and preserve the maximal normal liver parenchyma as a local treatment for hepatic tumors, which has been confirmed by many clinical studies [9][10][11] . These features are particularly important for patients with limited liver remanent after liver resection [10,11] .…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency ablation for postoperative recurrences of intrahepatic cholangiocarcinoma

Yang

et al. 2011

Chin. J. Cancer Res.

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Objective: Most recurrent intrahepatic cholangiocarcinoma (RICC) lost the opportunity of radical resection while most nonsurgical management failed to prolong patients' survival. The efficacy and safety of radiofrequency ablation (RFA) as a local treatment for recurrent hepatocellular carcinoma have been confirmed by many clinical studies. The purpose of this study was to evaluate the efficacy, long-term survival and complications of RFA for RICC.Methods: A total of 12 patients with 19 RICCs after radical resection were included in this study. The tumors were 1.9-6.8 cm at the maximum diameter (median, 3.2±1.6 cm). All patients were treated with ultrasound guided RFA. There were two RFA approaches including percutaneous and open.Results: A total of 18 RFA treatment sessions were performed. Ablation was successful (evaluated by 1-month CT after the initial RFA procedure) in 18 (94.7%) of 19 tumors. By a median follow-up period of 29.9 months after RFA, 5 patients received repeated RFA because of intrahepatic lesion recurrence. The median local recurrence-free survival period and median event-free survival period after RFA were 21.0 months and 13.0 months, respectively. The median overall survival was 30 months, and the 1-and 3-year survival rates were 87.5% and 37.5%, respectively. The complication rate was 5.6% (1/18 sessions). The only one major complication was pleural effusion requiring thoracentesis.Conclusion: This study showed RFA may effectively and safely manage RICC with 3-year survival of 37.5%. It provides a treatment option for these RICC patients who lost chance for surgery.

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The safety of radiofrequency thermal ablation in the treatment of liver malignancies

Cited by 14 publications

References 24 publications

Liver Function as Assessed by Breath Tests in Patients With Hepatocellular Carcinoma

Liver Function as Assessed by Breath Tests in Patients With Hepatocellular Carcinoma

SonoKnife: Feasibility of a line‐focused ultrasound device for thermal ablation therapy

Radiofrequency ablation for postoperative recurrences of intrahepatic cholangiocarcinoma

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