The safety of intraosseous infusions: Risks of fat and bone marrow emboli to the lungs

Orlowski, James P.; Julius, Carmen J.; Petras, Robert E.; Porembka, David T.; Gallagher, Jean M

doi:10.1016/s0196-0644(89)80932-1

Cited by 118 publications

(37 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7,11 Microscopic fat emboli do occur, but are considered too small to be clinically relevant. 12 Intraosseous infusion has been proved safe in both the prehospital and hospital settings as an aid to the resuscitation of injured or severely ill infants. 13 However, clinicians must take care during insertion to use sterile technique and sharp, strong needles of a size appropriate to the child being treated.…”

Section: Discussionmentioning

confidence: 99%

Tibial Fracture as a Complication of Intraosseous Infusion During Pediatric Resuscitation

Bowley

Loveland

Pitcher

2003

The Journal of Trauma: Injury, Infection, and Critical Care

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Tibial Fracture as a Complication of Intraosseous Infusion During Pediatric Resuscitation

Bowley

Loveland

Pitcher

2003

The Journal of Trauma: Injury, Infection, and Critical Care

View full text Add to dashboard Cite

“…Die Tatsache, dass im eigenen Kollektiv Komplikationen jedweder Art -insbesondere aber schwerwiegende -nicht festzustellen waren, wird auf mehrere Faktoren zurückgeführt: zum einen auf die standardisierte Vorgehensweise (standardisiertes Intraossär-Set sowie standardisiertes, steriles Vorgehen) und zum anderen auf die kurze Liegedauer der IO-Kanülen. In der Literatur wird die Entwicklung von (Spät)Komplikationen, insbesondere solche schwerwiegender Art, wie beispielsweise Osteomyelitis und Abszesse im Punktionsbereich, ganz wesentlich im Zusammenhang mit einer langen Liegedauer der präklinisch applizierten IO-Kanülen beobachtet [17,20,34]. Deshalb ist die Vorgehensweise des raschen innerklinischen Austausches der IO-Kanüle diesbezüglich von zentraler Bedeutung.…”

unclassified

Intraosseous puncture in preclinical emergency medicine

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Animal studies have shown fat particles in the lungs of dogs at post-mortem, nevertheless in human trials, adverse clinical outcomes in the form of respiratory complications or decreased oxygen saturation have not been reported [56]. Those subjects at a greater risk of embolization such as those with cardiac shunts should be considered as to their suitability to receive intraosseous BMAC.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology

Imam

Holton

Horriat

et al. 2017

SICOT-J

View full text Add to dashboard Cite

Tendon pathologies are a group of musculoskeletal conditions frequently seen in clinical practice. They can be broadly classified into traumatic, degenerative and overuse-related tendinopathies. Rotator cuff tears, Achilles tendinopathy and tennis elbow are common examples of these conditions. Conventional treatments have shown inconsistent outcomes and might fail to provide satisfactory clinical improvement. With the growing trend towards the use of mesenchymal stem cells (MSCs) in other branches of medicine, there is an increasing interest in treating tendon pathologies using the bone marrow MSC. In this article, we provide a systematic literature review documenting the current status of the use of bone marrow aspirate concentrate (BMAC) for the treatment of tendon pathologies. We also asked the question on the safety of BMAC and whether there are potential complications associated with BMAC therapy. Our hypothesis is that the use of BMAC provides safe clinical benefit when used for the treatment of tendinopathy or as a biological augmentation of tendon repair. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist while preparing this systematic review. A literature search was carried out including the online databases of PubMed, EMBASE, ClinicalTrial.gov and the Cochrane Library from 1960 to the end of May 2015. Relevant studies were selected and critically appraised. Data from eligible studies were extracted and classified per type of tendon pathology. We included 37 articles discussing the application and use of BMAC for the treatment of tendon pathologies. The Critical Appraisal Skills Program (CASP) appraisal confirmed a satisfactory standard of 37 studies. Studies were sub-categorised into: techniques of extraction, processing and microscopic examination of BMAC (n = 18), where five studies looked at the evaluation of aspiration techniques (n = 5), augmentation of rotator cuff tears (n = 5), augmentation of tendo-achilles tendon (n = 1), treatment of gluteal tendon injuries (n = 1), management of elbow epicondylitis (n = 2), management of patellar tendinopathy (n = 1) and complications related to BMAC (n = 5). Multiple experimental studies investigated the use of BMAC for tendon repair; nonetheless, there are only limited clinical studies available in this field. Unfortunately, due to the scarcity of studies, which were mainly case series, the current level of evidence is weak. We strongly recommend further future randomised controlled studies in this field to allow scientists and clinicians make evidence-based conclusions.

show abstract

The safety of intraosseous infusions: Risks of fat and bone marrow emboli to the lungs

Cited by 118 publications

References 24 publications

Tibial Fracture as a Complication of Intraosseous Infusion During Pediatric Resuscitation

Tibial Fracture as a Complication of Intraosseous Infusion During Pediatric Resuscitation

Intraosseous puncture in preclinical emergency medicine

A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology

Contact Info

Product

Resources

About