The safety of epidural spinal cord stimulation to restore function after spinal cord injury: post-surgical complications and incidence of cardiovascular events

Pino, Isabela Peña; Nightingale, Tom E.; Hoover, Caleb; Zhao, Zixi; Cahalan, Mark; Dorey, Tristan W.; Walter, Matthias; Soriano, Jan Elaine; Netoff, Theoden I.; Parr, Ann M.; Samadani, Uzma; Phillips, Aaron A.; Krassioukov, Andrei V.; Darrow, David

doi:10.1038/s41393-022-00822-w

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…This exciting work outlines one of the first clinical trials for transcutaneous spinal cord stimulation and autonomic function. This work complements the recent findings regarding the safety and efficacy of epidural spinal cord stimulation, along with various preclinical findings [6]. As neuromodulation after SCI shows promise, this non-invasive pilot trial will fill a critical gap in the literature and uncover future directions for the use of such stimulation after SCI.…”

Section: Electrical Neuromodulation To Improve Autonomic Function Aft...supporting

confidence: 60%

Recent updates in autonomic research: advances in the understanding of autonomic dysfunction after spinal cord injury

Lucci

2023

Clin Auton Res

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Section: Electrical Neuromodulation To Improve Autonomic Function Aft...supporting

confidence: 60%

Recent updates in autonomic research: advances in the understanding of autonomic dysfunction after spinal cord injury

Lucci

2023

Clin Auton Res

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“…SCI participants from the ESTAND study that had completed at least 7 of the follow-up sessions were included in this analysis. A detailed description of the study can be found in previous publications ( Darrow et al, 2019 ), ( Pino et al, 2020 ), ( Pino et al, 2022 ). In addition, nine healthy participants were also recruited to undergo the BMCA as controls for this study.…”

Section: Methodsmentioning

confidence: 99%

Epidural stimulation restores muscle synergies by modulating neural drives in participants with motor/sensory complete spinal cord injuries

Singh

Ahmadi

Parr

et al. 2022

Preprint

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Multiple studies have corroborated restored volitional motor control after motor-complete spinal cord injury (SCI) through the use of spinal cord stimulation (SCS/eSCS) but rigorous quantitative descriptions have been lacking. Using a structured surface electromyogram based (sEMG) task with and without SCS during the Epidural Stimulation After Neurological Damage (ESTAND) study in participants with chronic, motor and sensory complete SCI, we investigated muscle activity complexity and muscle synergies to better characterize neuro-muscular control.In addition, competition exists between the task and neural origin hypotheses underlying muscle synergies, and this analysis in humans with motor and sensory complete chronic injury provided an opportunity to test these hypotheses. Muscle activity complexity was computed with Higuchi Fractal Dimensional analysis (HFD), and muscle synergies were estimated using non-negative matrix factorization (NNMF) in six participants with AIS A chronic SCI. We found that the complexity of muscle activity is immediately reduced with SCS in the SCI participants. We also found that over the follow-up sessions, the muscle synergy structure of the SCI participants became more defined, and the number of synergies decreased over time, indicating improved coordination between the muscle groups. Lastly, we found that the muscle synergies were restored with SCS, supporting the neural hypothesis of muscle synergies. We conclude that SCS restores muscle movements and muscle synergies that are distinct from healthy, able-bodied controls.

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“…The inclusion of reporting adverse events in this category was guided by recent reviews indicating that scarce reporting of adverse events is a major limitation in the field [31,37,38,40]. Although reporting of surgical complications associated with implanted electrodes has been reported [71,72], adverse events associated with the delivery of SCS have not (e.g., burns, infections, pain, tissue damage). Notably, we excluded team qualifications, period, and duty cycle from the minimal reporting guidelines, as these characteristics did not meet the agreement cut-off.…”

Section: Figurementioning

confidence: 99%

REPORT-SCS: minimum reporting standards for spinal cord stimulation studies in spinal cord injury

Malik,

Samejima,

Shackleton

et al. 2024

J. Neural Eng.

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Objective:Electrical spinal cord stimulation (SCS) has emerged as a promising therapy for recovery of sensorimotor and autonomic dysfunctions following spinal cord injury (SCI). Despite the rise in studies using SCS for SCI complications, there are no standard guidelines for reporting SCS parameters in research publications, making it challenging to compare, interpret or reproduce reported effects across experimental studies.Approach:To develop guidelines for minimum reporting standards for SCS parameters in pre-clinical and clinical SCI research, we gathered an international panel of expert clinicians and scientists. Using a Delphi approach, we developed guideline items and surveyed the panel on their level of agreement for each item.Main Results:There was strong agreement on 26 of the 29 items identified for establishing minimum reporting standards for SCS studies. The guidelines encompass three major SCS categories: hardware, configuration and current parameters, and the intervention.Significance:Standardized reporting of stimulation parameters will ensure that SCS studies can be easily analysed, replicated, and interpreted by the scientific community, thereby expanding the SCS knowledge base and fostering transparency in reporting.

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The safety of epidural spinal cord stimulation to restore function after spinal cord injury: post-surgical complications and incidence of cardiovascular events

Abstract: The safety of epidural spinal cord stimulation to restore function after spinal cord injury: post-surgical complications and incidence of cardiovascular events',

Cited by 12 publications

References 33 publications

Recent updates in autonomic research: advances in the understanding of autonomic dysfunction after spinal cord injury

Recent updates in autonomic research: advances in the understanding of autonomic dysfunction after spinal cord injury

Epidural stimulation restores muscle synergies by modulating neural drives in participants with motor/sensory complete spinal cord injuries

REPORT-SCS: minimum reporting standards for spinal cord stimulation studies in spinal cord injury

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