The Safety of Definity and Optison for Ultrasound Image Enhancement: A Retrospective Analysis of 78,383 Administered Contrast Doses

Wei, Kevin; Mulvagh, Sharon L.; Carson, Lisa; Davidoff, Ravin; Gabriel, Ruvin; Grimm, Richard A.; Wilson, Stephanie R.; Fane, Lorrie; Herzog, Charles A.; Zoghbi, William A.; Taylor, Rhonda L.; Farrar, Michael W; Chaudhry, Farooq A.; Porter, Thomas R.; Irani, Waleed N.; Lang, Roberto M.

doi:10.1016/j.echo.2008.07.019

Cited by 235 publications

(162 citation statements)

References 23 publications

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“…The microbubbles must be stable enough to resist destruction from normal ultrasound power outputs to ensure adequate concentrations for imaging but may need to have the ability to rupture with high mechanical index ultrasound for some techniques to measure myocardial perfusion. 48 Although ultrasound contrast agents are generally considered safe, 49 the FDA issued a black-box warning for Definity and Optison, which, after a 2008 revision, recommends intensive monitoring for patients with pulmonary hypertension or unstable cardiopulmonary conditions and close observation of patients without these conditions. Currently there are no ultrasound contrast agents approved for MCE perfusion imaging, and the FDA considers it to be an experimental procedure.…”

Section: Contrast Agentsmentioning

confidence: 99%

Noninvasive Assessment of Myocardial Perfusion

Salerno

Beller

2009

Circ: Cardiovascular Imaging

182

142

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Section: Contrast Agentsmentioning

confidence: 99%

Noninvasive Assessment of Myocardial Perfusion

Salerno

Beller

2009

Circ: Cardiovascular Imaging

182

142

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“…Multicenter studies have shown that ultrasound contrast agents have an excellent safety profile with incidence of serious adverse events ranging from 0.0086% to 0.031% (24)(25)(26)(27). Furthermore, these contrast agents do not pose nephrotoxicity risks as they are fully excreted via the respiratory tract (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Contrast enhanced ultrasound guided biopsies of liver lesions not visualized on standard B-mode ultrasound—preliminary experience

Partovi

Kessner

et al. 2017

J. Gastrointest. Oncol.

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“…Hypersensitivity to octafluoropropane has also been reported. 18 It was recently shown that sonographic contrast agents provided a sensitive method for assessing the vascular distribution in the rotator cuffs of asymptomatic volunteers. 10,11 These studies showed diminished vascularity of the articular portion of the supraspinatus tendon, in keeping with the concept of a critical zone.…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Sonographic Characterization of the Vascularity of the Repaired Rotator Cuff

Adler

Johnson

Fealy

et al. 2011

Journal of Ultrasound in Medicine

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Objectives To characterize the distribution of vascularity of the postoperative rotator cuff tendon using a maximum intensity projection technique after contrast‐enhanced sonography. Methods We retrospectively evaluated image data on 23 patients (11 male and 12 female) with intact rotator cuff repairs who had previously undergone contrast‐enhanced sonography of their shoulders using lipid microspheres before and after a standardized exercise protocol. The patients were on average 3 months out from their surgery. Using offline image analysis software, a maximum intensity projection image was obtained for each patient, reflecting the regional vascular distribution within the repair and adjacent soft tissue. Subjective analysis was performed in 4 regions of interest: peribursal, articular medial, articular lateral, and suture anchor, independently by 2 musculoskeletal radiologists using a semiquantitative scale ranging from 0 to 4 for each region (0, no enhancement; 1, 1%–25% enhancement; 2, 26%–50%; 3, 51%–75%; and 4, 76%–100%). A combined vascularity score (0–8) was produced for each region and formed the basis for the subjective analysis. Results Using a Mann‐Whitney nonparametric test, the data showed significantly higher regional enhancement in the peribursal and suture anchor regions compared to the tendon (P < .001). Exercise resulted in a statistically significant increase in the extent of enhancement in all regions (P < .002). Inter‐rater reliability analysis using a weighted κ statistic showed strong agreement (0.63–0.64) for the suture anchor site and moderate agreement for the others (peribursal, 0.35–0.39; articular medial, 0.45–0.55; and articular lateral 0.32–0.33). Conclusions The maximum intensity projection technique after contrast‐enhanced sonography provides a topographic map of rotator cuff vascularity; the latter has been implicated as an important factor in promoting bone‐tendon healing. Approximately 3 months after rotator cuff repair, the suture anchor and peribursal regions showed the most robust vascularity. Maximum intensity projection imaging further establishes that there is a global increase in vascular response at the repair site after exercise.

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The Safety of Definity and Optison for Ultrasound Image Enhancement: A Retrospective Analysis of 78,383 Administered Contrast Doses

Cited by 235 publications

References 23 publications

Noninvasive Assessment of Myocardial Perfusion

Noninvasive Assessment of Myocardial Perfusion

Contrast enhanced ultrasound guided biopsies of liver lesions not visualized on standard B-mode ultrasound—preliminary experience

Contrast-Enhanced Sonographic Characterization of the Vascularity of the Repaired Rotator Cuff

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