The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities

Chambers, Christina D.; Krishnan, Jerry A.; Alba, Lorene; Albano, Jessica D.; Bryant, Allison; Carver, Melanie; Cohen, Lee S.; Gorodetsky, Elena; Hernández–Dı́az, Sonia; Honein, Margaret A.; Jones, Bridgette L.; Murray, Richard; Namazy, Jennifer A.; Şahin, Leyla; Spong, Catherine Y.; Vasisht, Kaveeta P.; Watt, Kevin M.; Wurst, Keele; Yao, Lynne; Schatz, Michael

doi:10.1016/j.jaci.2021.02.037

Cited by 14 publications

(11 citation statements)

References 79 publications

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“…Finally, regarding biological therapy, two recent reports have studied the use of omalizumab or anti-Ig-E without showing an increase in the risk of fetal malformations. While we have not found studies in the literature that approve the use of anti-IL5 drugs ( Bonham et al, 2018 ; Chambers et al, 2021 ) (Level of evidence III; 4. Grade of recommendation D).…”

Section: Respiratory Pathologymentioning

confidence: 90%

News in pharmacology for the main medical pathologies of gestation

De Guadalupe Quintana-Coronado,

Bravo,

Álvarez-Mon

et al. 2024

Front. Pharmacol.

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Obstetric diseases represent a highly complex medical challenge, especially regarding its clinical approach. The use of pharmacological agents during pregnancy is one of the main therapeutic alternatives in this group of patients; however, there is a general lack of knowledge about its use, efficacy, and possible adverse effects that may occur in routine clinical practice, even among medical professionals themselves. The high percentage of pregnant women who undergo drugs at some point during pregnancy, together with the developments that have occurred in recent years in the field of pharmacology, show the need for a detailed analysis that shows the existing current knowledge and helps in the clinical decision making. In this sense, the aim of this work is to conduct a review of the available scientific literature on the novelties in pharmacology for the main medical pathologies of pregnancy. Thus, the role of this field in analgesia, antibiotic therapy, digestive, respiratory, urological, psychiatric and neurological pathologies will be detailed, evaluating the indications, precautions and considerations that must be taken into account for its use.

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Section: Respiratory Pathologymentioning

confidence: 90%

News in pharmacology for the main medical pathologies of gestation

De Guadalupe Quintana-Coronado,

Bravo,

Álvarez-Mon

et al. 2024

Front. Pharmacol.

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“…Most asthma medications during pregnancy are regarded as well tolerated, especially when considering the maternal and fetal risks of uncontrolled asthma (Table 3). However, given the challenges of studying medication use in the pregnant population, including exclusion from clinical trials, lapses in knowledge remain [47].…”

Section: Management Of Severe Asthma In Pregnancymentioning

confidence: 99%

Asthma in pregnancy: a review of recent literature

Colas,

Namazy

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Asthma remains the most common respiratory disease in pregnancy. Identifying risk factors for asthma exacerbations during pregnancy is critical, as uncontrolled asthma can have detrimental effects for both mother and baby. In this review, we discuss recent literature exploring risk factors, fetal and maternal effects, and treatment options for asthma during pregnancy. Recent findings Recent literature suggests that optimizing asthma during pregnancy improves outcomes for both mother and baby, as well as later in childhood. Current research affirms that the benefit of asthma medication use outweighs any potential risks related to the medications themselves. Limited information is available regarding the use of newer therapies such as biologics during pregnancy. Summary Identifying risk factors for asthma exacerbations during pregnancy is critical to prevent adverse outcomes for both mother and baby. Recent evidence continues to affirm the safety of asthma medication use; more studies are needed regarding the use of new therapies during pregnancy.

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“…Due to potential risks, oral corticosteroids should be minimized, especially during pregnancy. Close collaboration between the asthma specialist and the obstetrician is essential to develop an appropriate treatment plan that balances asthma control with minimizing potential risks to the developing fetus [ 42 ].…”

Section: Reviewmentioning

confidence: 99%

Fertility Challenges in Asthmatic Women: Examining the Complexities of Pregnancy Loss, Infertility, and Assisted Reproductive Technologies

Shaikh,

Hirani

et al. 2023

Cureus

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Asthma is a prevalent chronic respiratory condition affecting a significant portion of women of reproductive age. While the impact of asthma on general health and well-being has been extensively studied, its association with fertility challenges in women remains an area of growing concern. This review article explores the complexities surrounding fertility challenges in asthmatic women, specifically focusing on pregnancy loss, infertility, and the utilization of assisted reproductive technologies (ARTs). Various factors contribute to the heightened risk of pregnancy loss in asthmatic women, including the systemic inflammation associated with asthma, suboptimal asthma control, medication usage, and comorbidities. The review highlights the need for multidisciplinary management approaches to optimize asthma control before and during pregnancy, reducing the risk of adverse pregnancy outcomes. Furthermore, the review investigates the potential impact of asthma on female fertility and the underlying mechanisms involved. Asthma-related factors, such as chronic inflammation, altered hormonal balance, and medication effects, may disrupt the delicate reproductive processes, leading to infertility. It emphasizes the importance of comprehensive fertility evaluations and personalized treatment strategies for asthmatic women experiencing difficulties conceiving. Additionally, the article explores the utilization of ARTs, including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), in asthmatic women. It discusses the safety considerations and potential challenges associated with these techniques, such as the impact of asthma medications on oocyte quality, the effects of hormonal stimulation on asthma control, and the risk of exacerbations during the IVF process. The review underscores the importance of collaborative efforts among healthcare providers, including allergists, pulmonologists, obstetricians, and fertility specialists, to ensure optimal management of asthmatic women seeking to conceive. It emphasizes the significance of preconception counseling, meticulous asthma control, appropriate medication management, and individualized fertility treatments to enhance the reproductive outcomes in this population.

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The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities

Cited by 14 publications

References 79 publications

News in pharmacology for the main medical pathologies of gestation

News in pharmacology for the main medical pathologies of gestation

Asthma in pregnancy: a review of recent literature

Fertility Challenges in Asthmatic Women: Examining the Complexities of Pregnancy Loss, Infertility, and Assisted Reproductive Technologies

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