The safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositis

Alexanderson, Christina H. S Helene

doi:10.1080/030097400447679

Cited by 121 publications

(28 citation statements)

References 24 publications

(23 reference statements)

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“…The beneficial effects of conventional resistance training in patients with PM and DM have been previously demonstrated [ 10 , 11 ]. Alexanderson et al .…”

Section: Discussionmentioning

confidence: 99%

Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis

et al. 2014

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IntroductionOur aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).MethodsIn total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.ResultsThe BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (−4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.ConclusionsWe demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.Trial registrationClinicaltrials.gov NCT01501019. Registered November 29, 2011.

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“…The beneficial effects of conventional resistance training in patients with PM and DM have been previously demonstrated [ 10 , 11 ]. Alexanderson et al .…”

Section: Discussionmentioning

confidence: 99%

Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis

et al. 2014

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“…133 A long-term follow-up study demonstrated that patients who have had JDM have persistently impaired fitness on maximal exercise using a cycle ergometer which is related to duration of active disease. 134 While other studies have reported the safety and benefits of resistive exercise in active patients one to three months into their treatment, 135 most of the studies have been in chronic PM or DM. 136 All studies demonstrated the efficacy and safety of exercise as measured by the Functional Index, SF-36, muscle histology, muscle MRI scanning, or CPK levels.…”

Section: Therapy For Dm Pm and Nmmentioning

confidence: 99%

Idiopathic Inflammatory Myopathies

2014

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The idiopathic inflammatory myopathies (IIM) consist of rare heterogenous autoimmune disorders that present with marked proximal and symmetric muscle weakness, except for distal and asymmetric weakness in inclusion body myositis (IBM). Besides frequent creatine kinase (CK) elevation, the electromyogram confirms the presence of an irritative myopathy. Extramuscular involvement affects a significant number of cases with interstitial lung disease (ILD), cutaneous in dermatomyositis (DM), systemic or joint manifestations and increased risk of malignancy especially in DM. Myositis specific autoantibodies influence phenotype of the IIM. Jo-1 antibodies are frequently associated with ILD and the newly described HMG-CoA reductase antibodies are characteristic of autoimmune necrotizing myopathy (NM). Muscle pathology ranges from inflammatory exudates of variable distribution, to intact muscle fiber invasion, necrosis, phagocytosis and in the case of IBM rimmed vacuoles and protein deposits. Despite many similarities, the IIM are a quite heterogeneous from the histopathological and pathogenetic standpoints in addition to some clinical and treatment-response difference. The field has witnessed significant advances in our understanding of pathophysiology and treatment of these rare disorders. In this review, we focus on DM, polymyositis (PM) and NM and examine current and promising therapies. The reader interested in more details on IBM is referred to the corresponding chapter in this issue.

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“…However, the %VC and PImax values did not improve satisfactorily compared to the knee extensor muscle strength and PEmax. Previous studies have reported improvements in knee extensor muscle strength and physical function in PM patients after physiotherapy, as evaluated via a functional index for myositis4,5,6, 16 ) . However, these studies did not evaluate the respiratory muscles.…”

Section: Discussionmentioning

confidence: 99%

Deviation in the recovery of the lower limb and respiratory muscles of patients with polymyositis: a preliminary clinical study

et al. 2016

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[Purpose] The purposes of this study were to quantify the serial changes in lower limb and respiratory muscle strengths and to evaluate the acute effects of physiotherapy in polymyositis patients. [Subjects and Methods] Five patients (57.6 ± 9.0 years, 50 to 72; four females) received physiotherapy five days a week for four weeks. The lower limb and respiratory muscle strength, the % vital capacity, and the Barthel index were evaluated at baseline and after the intervention. [Results] The patient’s symptoms and creatine kinase values did not change, and after four weeks, all of the patients exhibited significantly increased outcomes compared with the baseline. However, the inspiratory muscle strength of the patients presented smaller improvements than the expiratory muscle strength. [Conclusion] Differential changes in inspiratory and expiratory muscle strength were observed following physiotherapy, and an unbalanced muscle distribution may explain the pathological and therapeutic effects.

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The safety of a resistive home exercise program in patients with recent onset active polymyositis or dermatomyositis

Cited by 121 publications

References 24 publications

Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis

Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis

Idiopathic Inflammatory Myopathies

Deviation in the recovery of the lower limb and respiratory muscles of patients with polymyositis: a preliminary clinical study

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