The Safety and Predictability of Implanting Autologous Lenticule Obtained by SMILE for Hyperopia

Sun, Ling; Yao, Peng-Fei; Li, Meiyan; Shen, Yang; Zhao, Jing; Zhou, Xingtao

doi:10.3928/1081597x-20150521-03

Cited by 107 publications

(83 citation statements)

References 18 publications

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“…None of the eyes showed evidence of rejection in a mean follow‐up period of 155.4 days 7 or one year . Results suggest that refractive lenticules extracted after SMILE are safe and effective for use in human subjects . Most of these studies focused on safety, efficacy and predictability; however, as far as we know, there are currently no studies detailing changes to the human cornea after autologous lenticule implantation.…”

Section: Discussionmentioning

confidence: 97%

“…The perforations were successfully sealed in all six patients in the one‐year follow‐up period, indicating that corneal lenticules may be a safe and effective surgical alternative for corneal perforations. Ganesh et al and Sun et al used lenticules from SMILE surgeries to correct hyperopic eyes. None of the eyes showed evidence of rejection in a mean follow‐up period of 155.4 days 7 or one year .…”

Section: Discussionmentioning

confidence: 99%

“…Ganesh et al and Sun et al used lenticules from SMILE surgeries to correct hyperopic eyes. None of the eyes showed evidence of rejection in a mean follow‐up period of 155.4 days 7 or one year . Results suggest that refractive lenticules extracted after SMILE are safe and effective for use in human subjects .…”

Section: Discussionmentioning

confidence: 99%

“…The surgical techniques for the hyperopic eyes were previously described in another study . The target refraction of the hyperopic eye was ±0.50 D. A flap was made with the VisuMax femtosecond laser using a repetition rate of 500 kHz.…”

Section: Methodsmentioning

confidence: 99%

“…These results indicated that femtosecond laser‐assisted corneal lenticule transplantation in rabbits is feasible, and that the lenticule could thrive and integrate with the recipient stroma . In recent years, the results of autologous lenticule transplantation in human corneas, with follow‐up periods ranging from 38 days to one year, have indicated that this novel method for correcting hyperopia seems to be effective and safe, although its predictability should be improved in the future …”

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confidence: 95%

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In vivo confocal microscopic investigation of the cornea after autologous implantation of lenticules obtained through small incision lenticule extraction for treatment of hyperopia

Han

et al. 2018

Clinical and Experimental Optometry

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Purpose: To investigate re-innervation in the implanted lenticule, as well as changes to the cornea, after correcting hyperopia with an autologous implantation of a lenticule obtained through small incision lenticule extraction (SMILE). Methods: This study retrospectively analysed re-innervation in the implanted lenticule, as well as microscopic morphological changes in the corneal architecture of the recipient cornea in five patients (with myopia in one eye and hyperopia in the contralateral eye) who received SMILE in the myopic eye and femtosecond laser in situ keratomileusis (FS-LASIK) combined with lenticule implantation in the contralateral hyperopic eye. Re-innervation in the implanted lenticule, as well as microscopic morphological changes in corneal architecture, were evaluated by in vivo confocal microscopy. Results: One patient was examined at postoperative week six, two were examined at postoperative month two, one was examined at postoperative month nine, and one was examined at postoperative month 12. Partial subbasal nerve fibre regeneration was detected in two patients (Case 4 who was examined at postoperative month nine and Case 5 who was examined at postoperative month 12). Regenerated and branched nerve fibres were detected in the implanted lenticule in Case 5 who was examined at postoperative month 12. Both the anterior and posterior interfaces showed an absence or decrease of keratocytes and the presence of small particles of various brightnesses. Keratocytes in the implanted lenticule presented abnormal morphology in size and shape after surgery in all treated eyes, but showed partial morphological recovery in two patients (Case 4 who was examined at postoperative month nine and Case 5 who was examined at postoperative month 12). Conclusions: These preliminary findings suggest that nerve fibres will regenerate into the implanted lenticule after autologous lenticule implantation. Keratocytes in lenticules demonstrated a gradual return to a normal morphology.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 95%

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In vivo confocal microscopic investigation of the cornea after autologous implantation of lenticules obtained through small incision lenticule extraction for treatment of hyperopia

Han

et al. 2018

Clinical and Experimental Optometry

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Biologicals and Biomaterials for Corneal Regeneration and Vision Restoration in Limbal Stem Cell Deficiency

Di Girolamo

2024

Advanced Materials

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The mammalian cornea is decorated with stem cells bestowed with the life‐long task of renewing the epithelium, provided they remain healthy, functional and in sufficient numbers. If not, a debilitating disease known as limbal stem cell deficiency (LSCD) can develop causing blindness. Decades after the first stem cell (SC) therapy was devised to treat this condition, patients continue to suffer unacceptable failures. During this time, improvements to therapeutics have included identifying better markers to isolate robust SC populations and nurturing them on crudely modified biological or biomaterial scaffolds including human amniotic membrane, fibrin and contact lenses, prior to their delivery. Researchers are now gathering information about the biomolecular and biomechanical properties of the corneal SC niche to decipher what biological and/or synthetic materials can be incorporated into these carriers. Advances in biomedical engineering including electrospinning and 3D bioprinting with surface functionalization and micropatterning, and self‐assembly models, have generated a wealth of biocompatible, biodegradable, integrating scaffolds to choose from, some of which are being tested for their SC delivery capacity in the hope of improving clinical outcomes for patients with LSCD.This article is protected by copyright. All rights reserved

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Corneal Physiology: Corneal Form and Function

Klyce

Hallak

Romond

et al. 2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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The Safety and Predictability of Implanting Autologous Lenticule Obtained by SMILE for Hyperopia

Abstract: Implanting an autologous lenticule obtained by small incision lenticule extraction for hyperopia might be safe, effective, and stable, but its predictability should be improved in the future.

Cited by 107 publications

References 18 publications

In vivo confocal microscopic investigation of the cornea after autologous implantation of lenticules obtained through small incision lenticule extraction for treatment of hyperopia

In vivo confocal microscopic investigation of the cornea after autologous implantation of lenticules obtained through small incision lenticule extraction for treatment of hyperopia

Biologicals and Biomaterials for Corneal Regeneration and Vision Restoration in Limbal Stem Cell Deficiency

Corneal Physiology: Corneal Form and Function

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