“… 6 As summarized in Table 4 , responses are consistently worse in those vaccinated within the first six months to one year after transplantation. 8 , 9 , 14 , 16 , 18 , 22 , 23 , 24 , 25 , 30 , 66 Low lymphocyte counts, 8 , 23 , 29 , 66 low B cell 22 , 24 , 25 , 28 or NK cell counts, low CD4 counts 28 , low CD/CD8 ratio 24 , or low immunoglobulin levels 12 , 28 , 29 are all associated with poor response. Worse responses are found in those with GVHD, 9 , 10 , 23 , 30 those receiving immunosuppressants (particularly ibrutinib and ruxolitinib) 8 , 11 , 12 , 17 , 21 , 22 , 26 , 30 , 66 and those under active treatment for their underlying disease.…”