“…1 ), with a total of 17,140 participants [ 34 – 113 ]. Included trials were comprised of 54 (67.5%) pharmacological or sedation intervention studies [ 34 – 36 , 38 – 40 , 42 – 45 , 47 , 49 – 51 , 55 – 57 , 59 – 63 , 67 – 69 , 71 , 73 – 76 , 78 , 79 , 81 , 82 , 85 – 87 , 89 , 90 , 92 – 94 , 97 – 100 , 102 , 103 , 105 – 108 , 110 , 112 , 113 ] with 14,224 participants, 25 (31.3%) studies of non-pharmacological single or multi-component interventions with 2904 participants [ 37 , 41 , 46 , 48 , 52 , 53 , 57 , 58 , 64 – 66 , 70 , 72 , 77 , 80 , 83 , 84 , 88 , 91 , 95 , 96 , 101 , 104 , 109 , 111 ], and 1 study (1.2%) included a combination non-pharmacological with a pharmacological intervention with 12 participants [ 54 ]. Key features of all included trials are presented in detail in eTable 2.…”