The Russian welfare state: moving towards neofamilialism?

Effect of prooxidants on mitochondrail permeability transition and cell death in Ehrlich ascites tumour cells

“…In this paper we report data on the effect of prooxidants on the raPT in permeabilized and intact Ehrlich ascites tumour cells (EATC). In previous studies we have shown that mPT can be induced in EATC mitochondria in situ and that the pore can be regulated by well known raPT effectors such as CsA, ADP, polyamines and Mg 2+ [22,23]. In this study we demonstrate that with loads of Ca ~+ well below the threshold for induction of mPT, very small concentrations of prooxidants were able to induce mPTP opening.…”

“…It was earlier assumed that the higher CBC of EATC mitochondria was due to low or altered phospholipase A2 activity [28]. Now it is generally accepted that Ca 2+ -induced Ca 2+ release in mammalian mitochondria is due to the opening of a CsA-sensitive pore [29] which has been shown to be present also in EATC mitochondria and regulated in the same way by Mg 2+ , ADP and ATP [22,23]. One reason for the high CBC in tumour mitoehondria might Vol.…”