The Rumen Microbiota Contributes to the Development of Mastitis in Dairy Cows

Abstract

Mastitis is a common and frequently occurring disease of humans and animals, especially in dairy farming, which has caused huge economic losses and brought harmful substance residues, drug-resistant bacteria, and other public health risks. The traditional viewpoint indicates that mastitis is mainly caused by exogenous pathogenic bacteria infecting the mammary gland.

The Role of Rumen Microbiota and Its Metabolites in Subacute Ruminal Acidosis (SARA)-Induced Inflammatory Diseases of Ruminants

“…Mastitis induced by SARA is caused by endogenous pathogenic microorganisms and/or by endogenous bacterial metabolites from the rumen. Ours and other studies also showed that LPS concentrations in the rumen fluid and lacteal artery and vein increased in dairy cows with SARA induced by high-grain feeding [ 2 , 28 ]. Increased LPS could induce an inflammatory response in the mammary gland [ 2 , 28 ].…”

“…Ours and other studies also showed that LPS concentrations in the rumen fluid and lacteal artery and vein increased in dairy cows with SARA induced by high-grain feeding [ 2 , 28 ]. Increased LPS could induce an inflammatory response in the mammary gland [ 2 , 28 ]. Wang et al also showed that increased rumen iE-DAP was observed in long-term, high concentrate feeding-induced SARA, and increased iE-DAP could activate NOD1-NF-κB signaling pathway-dependent inflammation in the mammary gland of mid-lactating cows [ 17 ].…”

“…SARA will reduce milk yield and decrease the fat content of the milk of dairy cows [ 1 ]. Meanwhile, it causes a series of diseases, such as diarrhea, mastitis and laminitis, and causes huge economic losses to dairy farming [ 1 , 2 ].…”

“…The occurrence of the disease causes a decline in the milk yield and milk quality of dairy cows and brings huge economic losses to dairy farming. A large number of studies have shown a link between SARA and mastitis [ 2 , 27 ]. A recent study we conducted showed that somatic cell count (a well-established direct indicator of mastitis) increased in milk in a high-grain diet-induced SARA model of dairy cows [ 2 , 28 ].…”

“…A large number of studies have shown a link between SARA and mastitis [ 2 , 27 ]. A recent study we conducted showed that somatic cell count (a well-established direct indicator of mastitis) increased in milk in a high-grain diet-induced SARA model of dairy cows [ 2 , 28 ]. The results suggested that SARA could induce the occurrence of mastitis.…”