Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) Mitochondria and endoplasmic reticulum (ER) networks are interconnected, sharing structural and functional interactions essential for the maintenance of cellular homeostasis. The contacts between ER and mitochondria, known as mitochondria-associated ER membranes (MAMs), play a pivotal role in calcium (Ca 2+ ) signaling, lipid transport, energy metabolism, and cell survival (1). The physical interactions between both organelles depend on complementary membrane proteins, which tether the two organelles together at specific sites. For example, the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane interacts with the inositol 1,4,5-triphosphate receptor (IP3R) on the ER through the molecular chaperone glucoseregulated protein 75 (Grp75), allowing Ca 2+ transfer from the ER to mitochondria (2). Recently, mitofusin 2 (Mfn2)