The RTEL1 rs6010620 Polymorphism and Glioma Risk: a Meta-analysis Based on 12 Case-control Studies

Du, Shuli; Geng, Tingting; Tian, Feng; Chen, Cui-Ping; Jin, Tianbo; Chen, Chao

doi:10.7314/apjcp.2014.15.23.10175

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Therefore, loss of RTEL1 function induces shortening of telomeres and chromosomal breaks. Helicase is a key protein in the repair of single-strand breaks, by direct involvement in the repair (DSB) of the English double-strand break (Du et al, 2014). However, in this study the RTEL1-rs6010620 polymorphism showed no association with gliomas, corroborating a study in North American cases (Lee et al, 2011).…”

Section: Discussionsupporting

confidence: 77%

Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma

Calastri

Hattori

Rodrigues

et al. 2019

Asian Pac J Cancer Prev

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Section: Discussionsupporting

confidence: 77%

Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma

Calastri

Hattori

Rodrigues

et al. 2019

Asian Pac J Cancer Prev

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“…The age, gender, extent of resection, radiotherapy, chemotherapy, and histological grade, tumor size and range have been identified as potential contributors to the prognosis of glioma patients (Hayashi et al ., 2017; Guo et al ., 2019). Moreover, many genetic polymorphisms have been identified to be associated with the susceptibility to gliomas and as well as the prognosis of glioma patients (Li et al ., 2013; Du et al ., 2014; Jin et al ., 2016). Therefore, it is critical to identify new glioma therapeutic targets and new diagnostic and prognostic biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Role of PVT1 polymorphisms in the glioma susceptibility and prognosis

Ding¹,

Zhao²,

Yuan³

et al. 2021

European Journal of Cancer Prevention

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Background: Genetic factors play a crucial role in the glioma risk and prognosis of glioma patients. To explore the role of PVT1 polymorphism in the susceptibility and survival of glioma in the Chinese Han population, we conducted a case-control study.Methods: The three single-nucleotide polymorphisms (SNPs) in PVT1 were genotyped using Agena MassARRAY from 575 patients with glioma and 500 healthy controls. We used the χ 2 test to analyze the differences in distribution of allele and genotype between the cases and controls. Odds ratio (OR) and 95% con dence interval (95% CI) were calculated by logistic regression analysis to evaluate the association SNPs with glioma risk. The effects of polymorphisms and clinical features on survival of glioma patients were evaluated using the log-rank test, Kaplan-Meier and Cox regression analysis.Results: We found that rs13255292 was associated with a decreased risk of glioma in the recessive model in overall or male; and rs4410871 was signi cantly associated with an increased the risk of glioma in age≤40 years old or female. Moreover, the extent of resection and chemotherapy were found to be key prognostic factors in survival of glioma patients. However, the gender, age, tumor grade, radiotherapy and PVT1 polymorphisms have no effect on prognosis of glioma patients.Conclusions: Our results indicated that PVT1 polymorphisms (rs13255292 and rs4410871) were associated with glioma susceptibility, but have no effect on prognosis of glioma patients. Further studies with large samples are required to con rm the results.

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“…The age, gender, extent of resection, radiotherapy, chemotherapy, and histological grade, tumor size and range have been identified as potential contributors to the prognosis of glioma patients [5,6]. Moreover, many genetic polymorphisms have been identified to be associated with the susceptibility to gliomas and as well as the prognosis of glioma patients [7][8][9]. Therefore, it is critical to identify new glioma therapeutic targets and new diagnostic and prognostic biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Role of PVT1 Polymorphisms in the Glioma Susceptibility and Prognosis

Ding

Zhao

Yuan

et al. 2020

Preprint

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Background: Genetic factors play a crucial role in the glioma risk and prognosis of glioma patients. To explore the role of PVT1 polymorphism in the susceptibility and survival of glioma in the Chinese Han population, we conducted a case-control study.Methods: The three single-nucleotide polymorphisms (SNPs) in PVT1 were genotyped using Agena MassARRAY from 575 patients with glioma and 500 healthy controls. We used the χ 2 test to analyze the differences in distribution of allele and genotype between the cases and controls. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated by logistic regression analysis to evaluate the association SNPs with glioma risk. The effects of polymorphisms and clinical features on survival of glioma patients were evaluated using the log-rank test, Kaplan-Meier and Cox regression analysis.Results: We found that rs13255292 was associated with a decreased risk of glioma in the recessive model in overall or male; and rs4410871 was significantly associated with an increased the risk of glioma in age≤40 years old or female. Moreover, the extent of resection and chemotherapy were found to be key prognostic factors in survival of glioma patients. However, the gender, age, tumor grade, radiotherapy and PVT1 polymorphisms have no effect on prognosis of glioma patients.Conclusions: Our results indicated that PVT1 polymorphisms (rs13255292 and rs4410871) were associated with glioma susceptibility, but have no effect on prognosis of glioma patients. Further studies with large samples are required to confirm the results.

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The RTEL1 rs6010620 Polymorphism and Glioma Risk: a Meta-analysis Based on 12 Case-control Studies

Cited by 8 publications

References 27 publications

Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma

Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma

Role of PVT1 polymorphisms in the glioma susceptibility and prognosis

Role of PVT1 Polymorphisms in the Glioma Susceptibility and Prognosis

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