The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China

Liu, Huawei; Wei, Daixu; He, Dawei; Deng, Jiuzheng; Zhu, Jianjin; Xu, Kai; Hu, Dong; Li, Jing; Hu, Wenhao; Wang, Yan; Xiao, Shifu; Fu, Ligong

doi:10.12659/msm.920956

Cited by 1 publication

(4 citation statements)

References 27 publications

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“…FCRLs are a class of proteins similar to Fc receptors, which play an important role in maintaining the homeostasis of the immune system (Tolnay, 2022). FCRL gene belongs to the immunoglobulin gene superfamily, of which FCRL5 is an important member and has been reported to play a crucial part in the regulatory mechanism of immune cells (Liu et al, 2020). A previous study demonstrated that FCRL5 exerts binary and compartment-specific influence on innatelike B-cell receptor signaling, and implied a specialized counterregulatory role for FCRL5 at the intersection of innate and adaptive immunity (Zhu et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Simmonds et al (2010) found that rs6692977 mutation was associated with the occurrence of hyperthyroidism, with a higher frequency of the T allele in the case group compared to the control population. Liu et al (2020) showed that rs6427384 polymorphisms of the FCRL5 gene were Associations of demographic and clinical characteristics with FCRL5 mRNA expression levels. FCRL5, Fc receptor-like 5.…”

Section: Discussionmentioning

confidence: 99%

“…Fc receptor-like molecules (FCRLs) are a class of proteins similar to Fc receptors that play an important role in maintaining the homeostasis balance of the immune system (Li et al, 2014b). The FCRL genes are members of the immunoglobulin gene superfamily, discovered by multiple teams using different strategies, and scholars eventually designated them as a uniform nomenclature (Liu et al, 2020). In recent years, a large of studies have found that FCRLs play a vital role in immunodeficiencies, virus infections, and autoimmune diseases (Ehrhardt and Cooper, 2011;Li et al, 2014a;Davis, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…FCRL5 can regulate immune response by affecting the signal transduction of immune cell receptors (Zhu et al, 2013). Genetic mutations in the FCRL5 gene may affect the transcription and translation processes, thus altering its protein expression levels and modifying its protein function (Liu et al, 2020). Previous studies have shown that FCRL5 gene variants were associated with several immune and inflammatory diseases such as allergic rhinitis (Gu et al, 2019), Graves' disease (Simmonds et al, 2010), and ankylosing spondylitis (Liu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Fc receptor-like 5 gene polymorphisms and mRNA expression are associated with liver fibrosis in chronic hepatitis B

Yang

Wang

et al. 2022

Front. Microbiol.

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Objective: To investigate the associations of Fc receptor-like 5 (FCRL5) gene polymorphisms and mRNA expression with liver fibrosis in chronic hepatitis B (CHB).Methods: A total of 114 CHB patients with liver fibrosis and 120 CHB patients without liver fibrosis were selected for this study. The gender, age, body mass index (BMI), alanine transaminase (ALT) value, aspartate aminotransferase (AST) value, aspartate aminotransferase-to-platelet ratio index (APRI), and fibrosis index based on 4 factors (FIB-4) were recorded. Two polymorphisms of the FCRL5 gene (rs6427384 and rs6692977) were genotyped. The mRNA expression level of FCRL5 in peripheral blood monocytes was determined.Results: ALT, AST, APRI, and FIB-4 in patients with fibrosis were significantly higher than those in non-fibrosis patients. There was statistically significant difference between fibrosis and non-fibrosis groups in the genotype distribution (χ2 = 7.805, p = 0.020) and allele frequencies (χ2 = 13.252, p < 0.001) at FCRL5 rs6692977. When compared with CC genotype, the genotype CT or TT at rs6692977 was significantly associated with a increased risk of liver fibrosis in CHB patients (CT vs. CC: OR = 1.921, 95% CI = 1.093–3.375, p = 0.023; TT vs. CC: OR = 2.598, 95% CI = 1.067–6.324, p = 0.031). The mRNA relative expression levels of FCRL5 in patients with liver fibrosis were significantly higher than those in the non-fibrosis group (t = 13.456, p < 0.001). The fibrosis patients carried TT or CT genotype of rs6692977 had significantly higher FCRL5 mRNA expression levels than those carried CC genotype (t = 2.859, p = 0.005). The mRNA expression levels of FCRL5, APRI, and FIB-4 index showed predictive efficacy in liver fibrosis with cut-off values of 0.75 (AUC = 0.896, 95% CI = 0.856–0.935), 0.45 (AUC = 0.852, 95% CI = 0.802–0.902) and 1.84 (AUC = 0.765, 95% CI = 0.703–0.826), respectively.Conclusion: FCRL5 gene rs6692977 polymorphisms and mRNA expression levels are associated with liver fibrosis in CHB patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%