The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health

Li, Xiaohan; He, Lan; Liu, Jinting; Guo, Wenxuan; Wang, Quanhe; Fang, Pengpeng; Yang, Xing; Zhang, Mengfei; Wang, Chunlan; Gong, Pingyuan

doi:10.1016/j.jad.2020.03.153

Cited by 12 publications

(7 citation statements)

References 65 publications

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“…The major G/G genotype was associated with a lower level of emotional in-telligence. Our results do not contradict the results of another study, where it was indicated that the G allele of rs6311 was related to higher scores on the Toronto Alexithymia Scale compared to the AA genotype (Li et al, 2020). In studies on samples of patients with schizophrenia, it was shown that schizophrenia patients more often carry the major genotype C/C of the HTR2A gene to a statistically significant extent (this corresponds to G/G, since the loci rs6313 C>T and rs6311 G>A are in non-equilibrium coupling), while having a low density of serotonin 2A receptors in the brain (Polesskaya et al, 2002;Parsons et al, 2004).…”

Section: Discussionsupporting

confidence: 60%

Emotional Intelligence in Carriers of Different СОМТ, BDNF, DRD2 and HTR2A Genotypes

Vorobyeva¹,

Kovsh²,

Kosonogov³

2022

Psych. Rus.

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Background. Emotional intelligence is the ability to quickly and correctly recognize the emotional expressions of other people and to express and manage one’s own emotions. It contributes to the success of a person in activities related to communication and interaction with people. Emotional intelligence has been studied largely in the context of organizational and education psychology, but less is known about the influence of genetics on it. Objective. We aim to study emotional intelligence in carriers of different СОМТ, BDNF, DRD2, and HTR2A genotypes. Design. We used three methods to measure emotional intelligence. Mayer-Salovey-Caruso Emotional Intelligence Test is a set of tasks with forced choice and frequency-based correct responses. We also applied two self-report questionnaires by Lyusin and Hall. We recruited 280 participants who took part in all three measures. We also identified their genotypes of the СОМТ, BDNF, DRD2, and HTR2A genes. Results. Carriers of the Val/Met genotype of the COMT gene, A/A genotype of the HTR2A gene and C/C genotype of the DRD2 gene showed the highest level of emotional intelligence, while no differences were found between carriers of the BDNF genotypes. These data were obtained by using the Mayer-Salovey-Caruso Emotional Intelligence Test. Self-report scores of emotional intelligence did not differ between carriers of different genotypes across all four of the genes in question. Conclusion. Mayer-Salovey-Caruso Emotional Intelligence Test scores were differed for carriers of some genotypes, whereas self-reported emotional intelligence scores did not differ between according to genotype.

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Section: Discussionsupporting

confidence: 60%

Emotional Intelligence in Carriers of Different СОМТ, BDNF, DRD2 and HTR2A Genotypes

Vorobyeva¹,

Kovsh²,

Kosonogov³

2022

Psych. Rus.

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“…Based on findings from genetic and neurobiological studies, which suggested that disturbed serotonergic neurotransmission underlies the development of both, depressive disorders (Kraus et al ., 2017) as well as alexithymia (Gong et al ., 2014; Terock, et al ., 2018; Li et al ., 2020; Terock, et al ., 2021a), it could be speculated that vitamin D impacts on these conditions via an interaction with the central serotonergic metabolism. In fact, there is growing evidence that vitamin D, binding to intracellular vitamin D receptors and subsequently to promotor regions (Uitterlinden et al ., 2004), regulates the expression of various genes of the serotonergic pathway: For example, the expression of tryptophan hydroxylase 2 (TPH-2), the initial and rate-limiting enzyme in the biosynthesis of serotonin, was found to be associated with various neuropsychiatric disorders, including depression (Ottenhof et al ., 2018) and its expression is regulated by activated vitamin D (Kaneko et al ., 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Finding high associations of alexithymia with a history of traumatic events (Yehuda et al ., 1997; Terock et al ., 2018) as well as trauma-associated psychiatric conditions like post-traumatic stress disorder (PTSD) (Söndergaard and Theorell, 2004; Frewen et al ., 2006; McCaslin et al ., 2006) or dissociation (Craparo et al ., 2014; Terock et al ., 2016) led to the concept of alexithymia as a defense mechanism against intolerable thoughts and feelings. However, evidence from genetic (Gong et al ., 2014; Li et al ., 2020) and neurobiological studies suggested that in addition to environmental factors, biological variables such as neuroendocrine alterations (Härtwig et al ., 2013), behavioral or nutritional characteristics (Helmers and Mente, 1999) are involved in the pathophysiology of alexithymia.…”

Section: Introductionmentioning

confidence: 99%

Alexithymia is associated with reduced vitamin D levels, but not polymorphisms of the vitamin D binding-protein gene

Terock

Hannemann

Weihs

et al. 2021

Psychiatric Genetics

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Objective Alexithymia is a personality trait characterized by difficulties in identifying and describing emotions, which is associated with various psychiatric disorders, including depression and posttraumatic stress disorder (PTSD). Its pathogenesis is incompletely understood but previous studies suggested that genetic as well as metabolic factors, are involved. However, no results on the role of vitamin D and the polymorphisms rs4588 and rs7041 of the vitamin D binding protein (VDBP) have been published so far.Methods Serum levels of total 25(OH)D were measured in two general-population samples (total n = 5733) of the Study of Health in Pomerania (SHIP). The Toronto Alexithymia Scale-20 (TAS-20) was applied to measure alexithymia. Study participants were genotyped for rs4588 and rs7041. Linear and logistic regression analyses adjusted for sex, age, waist circumference, physical activity, season and study and, when applicable, for the batch of genotyping and the first three genetic principal components, were performed. In sensitivity analyses, the models were additionally adjusted for depressive symptoms.Results 25(OH)D levels were negatively associated with TAS-20 scores (β = −0.002; P < 0.001) and alexithymia according to the common cutoff of TAS-20>60 (β = −0.103; P < 0.001). These results remained stable after adjusting for depressive symptoms. The tested genetic polymorphisms were not significantly associated with alexithymia.Conclusions Our results suggest that low vitamin D levels may be involved in the pathophysiology of alexithymia. Given that no associations between alexithymia and rs4588 as well as rs7041 were observed, indicates that behavioral or nutritional features of alexithymic subjects could also explain this association.

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“…5-HT is related to many affective and executive functions. Related researches have indicated that 5-HT is associated with anxiety ( Deakin and Graeff, 1991 ), depression ( Kraus et al, 2017 ), alexithymia ( Li et al, 2020 ), and emotion regulation disorder ( Stiedl et al, 2009 ). Meanwhile, the function of 5-HT and FND patients in rewarding and aversion processing has received more and more attention.…”

Section: Dopamine and Serotoninmentioning

confidence: 99%

The Aversion Function of the Limbic Dopaminergic Neurons and Their Roles in Functional Neurological Disorders

Zheng-ming

Jiang

et al. 2021

Front. Cell Dev. Biol.

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The Freudian theory of conversion suggested that the major symptoms of functional neurological disorders (FNDs) are due to internal conflicts at motivation, especially at the sex drive or libido. FND patients might behave properly at rewarding situations, but they do not know how to behave at aversive situations. Sex drive is the major source of dopamine (DA) release in the limbic area; however, the neural mechanism involved in FND is not clear. Dopaminergic (DAergic) neurons have been shown to play a key role in processing motivation-related information. Recently, DAergic neurons are found to be involved in reward-related prediction error, as well as the prediction of aversive information. Therefore, it is suggested that DA might change the rewarding reactions to aversive reactions at internal conflicts of FND. So DAergic neurons in the limbic areas might induce two major motivational functions: reward and aversion at internal conflicts. This article reviewed the recent advances on studies about DAergic neurons involved in aversive stimulus processing at internal conflicts and summarizes several neural pathways, including four limbic system brain regions, which are involved in the processing of aversion. Then the article discussed the vital function of these neural circuits in addictive behavior, depression treatment, and FNDs. In all, this review provided a prospect for future research on the aversion function of limbic system DA neurons and the therapy of FNDs.

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The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health

Cited by 12 publications

References 65 publications

Emotional Intelligence in Carriers of Different СОМТ, BDNF, DRD2 and HTR2A Genotypes

Emotional Intelligence in Carriers of Different СОМТ, BDNF, DRD2 and HTR2A Genotypes

Alexithymia is associated with reduced vitamin D levels, but not polymorphisms of the vitamin D binding-protein gene

The Aversion Function of the Limbic Dopaminergic Neurons and Their Roles in Functional Neurological Disorders

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