The Routine Use of Tolbutamide in Unselected Patients in a Large Diabetic Outpatient Clinic

A Two and a Half Year Study of Chlorpropamide in a Large Outpatient Clinic

“…Management of diabetes mellitus in a very large outpatient clinic is so replete with problems that the introduction of oral hypoglycemic agents in 1957 was a most welcome simplification of therapy for control of this disease. Our initial experience with an oral sulfonylurea hypoglycemic agent, tolbutamide, was reported in 1960 (1).…”