The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning

Bissière, Stéphanie; Plachta, Nicolas; Hoyer, Daniel; McAllister, Kevin H.; Olpe, Hans‐Rudolf; Grace, Anthony A.; Cryan, John F.

doi:10.1016/j.biopsych.2007.10.022

Cited by 127 publications

(89 citation statements)

References 106 publications

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“…Similarly, chemical activation of ACC neurons in rodents induces aversion to the place where the activation occurred 43 . Conversely, bilateral (but not unilateral) chemical inactivation of the ACC inhibited the formation of conditioned fear memory induced by footshock 115,119,120 . Bilateral microinjection of NMDA-receptor antagonists into the ACC also reduced or blocked the formation of a fear memory 57 .…”

Section: Box 1 | Pain Fear and The Anterior Cingulate Cortexmentioning

confidence: 96%

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

et al. 2016

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The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this Review, we discuss increasing evidence from rodent studies that ACC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect. In particular, one form of long-term potentiation (LTP) in the ACC, which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP in the ACC, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.

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Section: Box 1 | Pain Fear and The Anterior Cingulate Cortexmentioning

confidence: 96%

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

et al. 2016

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“…Thus, the ACC (and the mPFC in general) are key structures in determining how we deal with the world and are central to inhibitory control (Braver, Barch, Gray, Molfese, & Snyder, 2001;Rubia et al, 2001), reward responses and their modulation (Amiez, Joseph, & Procyk, 2005), aVective resilience (Bissiere et al, 2008;Etkin, Egner, Peraza, Kandel, & Hirsch, 2006), and even top-down inXuence on primary sensory processes (Crottaz-Herbette & Menon, 2006;Sarter, Gehring, & Kozak, 2006) and presumably for higher level functions as well (Koski & Paus, 2000). In other words, the ACC and mPFC are central to control mechanisms dealing with internal states.…”

Section: What Does the Acc Do?mentioning

confidence: 98%

Individual differences and developmental change in the ERN response: implications for models of ACC function

Segalowitz

Dywan

2008

Psychological Research

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The anterior cingulate cortex (ACC) has been associated with conditions precipitating an increase in effortful processing or increased attention, including the presence of conflicting information and the detection of errors. The error-related negativity (ERN), an electrocortical response, has been used as a marker for these conditions. The ERN amplitude however is subject to developmental change across the lifespan as well as being sensitive to individual differences in personality, affect, and autonomic responsivity. In this review, we examine the implications of such influences for a standard ACC model of conflict processing, and outline the need of any model of ACC function to include mechanisms that allow for the integration of neurovisceral and cognitive domains.

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“…A role for the ACC in trace conditioning is further supported by work that found pre-training blockade of NR2B containing NMDARs within the ACC disrupted trace fear in mice (Descalzi et al, 2012). Similar to the PL, the rodent ACC also sends excitatory projections to the amygdala and thus may alter fear expression directly (Bissière et al, 2008). In support, mice with pre-training ACC inactivation showed initial deficits in fear acquisition in a delay fear paradigm (Bissière et al, 2008), conversely humans showed increased ACC activation during both delay and trace fear conditioning (Knight et al, 2004; Milad et al, 2007).…”

Section: Working Memory and Trace Conditioningmentioning

confidence: 99%

The role of working memory and declarative memory in trace conditioning

Connor

Gould

2016

Neurobiology of Learning and Memory

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Translational assays of cognition that are similarly implemented in both lower and higher-order species, such as rodents and primates, provide a means to reconcile preclinical modeling of psychiatric neuropathology and clinical research. To this end, Pavlovian conditioning has provided a useful tool for investigating cognitive processes in both lab animal models and humans. This review focuses on trace conditioning, a form of Pavlovian conditioning typified by the insertion of a temporal gap (i.e., trace interval) between presentations of a conditioned stimulus (CS) and an unconditioned stimulus (US). This review aims to discuss pre-clinical and clinical work investigating the mnemonic processes recruited for trace conditioning. Much work suggests that trace conditioning involves unique neurocognitive mechanisms to facilitate formation of trace memories in contrast to standard Pavlovian conditioning. For example, the hippocampus and prefrontal cortex (PFC) appear to play critical roles in trace conditioning. Moreover, cognitive mechanistic accounts in human studies suggest that working memory and declarative memory processes are engaged to facilitate formation of trace memories. The aim of this review is to integrate cognitive and neurobiological accounts of trace conditioning from preclinical and clinical studies to examine involvement of working and declarative memory.

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The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning

Cited by 127 publications

References 106 publications

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

Individual differences and developmental change in the ERN response: implications for models of ACC function

The role of working memory and declarative memory in trace conditioning

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