The Roots of Veterinary Botanical Medicine

Wynn, Susan G.; Fougère, Barbara J.

doi:10.1016/b978-0-323-02998-8.50008-1

Cited by 7 publications

(12 citation statements)

References 4 publications

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“…YNB can be prepared in several ways (powder, capsule, aerosol and tincture) for local or oral application. Although the precise herbal formula of YNB is a trade secret, the product is now labeled to identify the major components of each 0.5 g serving ( 37 ). The 2011 manufacturer's label listed the following compounds; 200 mg Tienchi ginseng root (Panax notoginseng), 85 mg Ajuga forrestii Diels plant, 66.5 mg Chinese yam root, 57.5 mg Dioscoreae nipponica Makino root, 36 mg Erodium stephanianum and Geranium wilfordii plant, 30 mg Dioscoreae parvilora ting root and 25 mg Inula cappa plant ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

Ren

Zhang

Chen

et al. 2017

Molecular Medicine Reports

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The traditional Chinese medicine Yunnan Baiyao (YNB) has been reported to possess anti-inflammatory properties, however its mechanism of action remains unclear. It was previously reported that YNB ameliorated depression of arachidonic acid (AA) levels in a rat model of collagen-induced arthritis. In the current study, the capacity of YNB to ameliorate inflammation was compared in carrageenan-induced and AA-induced acute inflammation of the rat paw with celecoxib and mizolastine, respectively (n=24 per group). The capacity of YNB to affect the phospholipase A2 (PLA2)/AA pathway (using reverse transcription-quantitative polymerase chain reaction) and release of inflammatory lipid mediators (by ELISA) were investigated. Celecoxib ameliorated carrageenan-induced paw edema, and mizolastine ameliorated AA-induced rat paw edema. YNB alleviated paw edema and inhibited inflammatory cell infiltration in the two models. YNB inhibited production of 5-LOX AA metabolite leukotriene B4 (LTB4), and suppressed expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model (P<0.05). YNB Inhibited the production of the COX-2 AA metabolite prostaglandin E2 (PGE2) and suppressed expression of COX-2, cPLA2, PGE2 mRNA in the carrageenan-induced inflammation mode (P<0.05). Taken together, the data suggest that modulation of COX and LOX pathways in AA metabolism represent a novel anti-inflammatory mechanism of YNB.

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Section: Discussionmentioning

confidence: 99%

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

Ren

Zhang

Chen

et al. 2017

Molecular Medicine Reports

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“… Included in the AHPA class 2b. (not to be used during pregnancy), as well as in the list of generally recognized as safe when used as a spice or flavoring 80 . Myopathy in ruminants 80 .…”

Section: Resultsmentioning

confidence: 99%

“…(not to be used during pregnancy), as well as in the list of generally recognized as safe when used as a spice or flavoring 80 . Myopathy in ruminants 80 . Some serious toxicological side effects, such as teratogenic, reproductive (antifertility, abortifacient), effects, neurotoxicity, and other cellular and molecular alterations, not without controversy, have been reported 81 , 82 , 83 , 84 .…”

Section: Resultsmentioning

confidence: 99%

“… Classified as the American Herbal Products Association (AHPA) classes 2b (not to be used during pregnancy), 2c (not to be used while nursing), and 2 d (other specific use restrictions such as not to be used in persons with any inflammatory condition of the intestines) and contraindicated in children under 12 years of age 22 , 23 . It is not known if similar side effects will occur in animals.…”

Section: Resultsmentioning

confidence: 99%

“…Studies in animal models suggest a low acute toxic potential of fenugreek seeds by oral route at 2 and 5 g/kg bw in mice and rats, respectively, and intraperitoneal route at 0.65 and 3.5 g/kg bw in mice and rats, respectively 81 . As described in cattle 80 , myopathy may be caused by feeding cattle solely on fenugreek straw, leading to intoxication or an induced deficiency state 110 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ethnoveterinary Uses of Certain Yemeni Plants: A Review of the Scientific Evidence

Alasbahi

Groot

2021

Planta Med

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Livestock is an important and integral component of agriculture production in Yemen and contributes 28% of the total agricultural production income. Research in the field of Yemeni ethnoveterinary medicine is limited to a few studies. Therefore, our work aims to substantiate scientifically the ethnoveterinary use of some documented plant species based on a literature review of their bioactivities and toxicological properties. Searching the scientific literature has revealed various pharmacological activities that may support the claimed healing activities of 11 out of 14 plant species for some of their ethnoveterinary utilization. This comprises the use of Aloe spp. latex for constipation, worms, boils, and wounds; Boswellia sacra underbark for wounds and its oleo-gum resin for mastitis; Soqotraen Boswellia species as an insect repellent; Cissus rotundifolia for stomach pain; Cyphostemma digitatum as an appetite stimulant; Psiadia punctulate for bone fracture; Pulicaria undulata as an insect repellent; combinations of Aristolochia bracteolate with Sorghum bicolor grains for bloating; Rumex nervosus and salt for eye pimples; and Trigonella foenum-graecum seeds with Hordeum vulgare grains for constipation. Some plants were found to demonstrate various toxic effects in in vivo and in vitro experimental studies. The local administration of Calotropis procera latex was also reported to induce an intense inflammatory response. It can be concluded that our work has provided valuable scientific information on the biological and toxic activities of some Yemeni ethnoveterinary remedies that could be utilized for the benefit of farmers to ration the use of these remedies and avoiding their toxicity.

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African Plants with Potential for Development into Ethnoveterinary Products

McGaw

Eloff

2014

Novel Plant Bioresources

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The Roots of Veterinary Botanical Medicine

Cited by 7 publications

References 4 publications

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

Ethnoveterinary Uses of Certain Yemeni Plants: A Review of the Scientific Evidence

African Plants with Potential for Development into Ethnoveterinary Products

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