The Roles Potassium Currents Play in Regulating the Electrical Activity of Ventral Cochlear Nucleus Neurons

Rothman, Jason S.; Manis, Paul B.

doi:10.1152/jn.00127.2002

Cited by 264 publications

(401 citation statements)

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“…Computational modeling also supports the importance of leak conductances in stellate (Type I) cells in the cochlear nucleus (Rothman and Manis, 2003). The leak conductance in Type II neurons appears to be small relative to other potassium conductances.…”

Section: Neuronal Excitabilitymentioning

confidence: 62%

“…There is evidence from empirical observations and computational modeling that channels are in a position to influence neural excitability in cochlear nucleus neurons (Fujino and Oertel, 2001;Rothman and Manis, 2003). In the ventral cochlear nucleus, muscarinic receptor activation excites stellate cells by blocking potassium leak currents (Fujino and Oertel, 2001).…”

Section: Neuronal Excitabilitymentioning

confidence: 99%

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Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus

et al. 2006

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Two-pore domain potassium channels ( ) play an important role in setting resting membrane potential by regulating background leakage of potassium ions, which in turn controls neuronal excitability. To determine whether these channels contribute to activity-dependent plasticity following deafness, we used quantitative real-time PCR to examine the expression of 10 subunits in the rat cochlear nucleus at 3 days, 3 weeks and 3 months after bilateral cochlear ablation. There was a large sustained decrease in the expression of TASK-5, a subunit that is predominantly expressed in auditory brain stem neurons, and in the TASK-1 subunit which is highly expressed in several types of cochlear nucleus neurons. TWIK-1 and THIK-2 also showed significant decreases in expression that were maintained across all time points. TWIK-2, TREK-1 and TREK-2 showed no significant change in expression at 3 days but showed large decreases at 3 weeks and 3 months following deafness. TRAAK and TASK-3 subunits showed significant decreases at 3 days and 3 weeks following deafness, but these differences were no longer significant at 3 months. Dramatic changes in expression of subunits suggest these channels may play a role in deafness-associated changes in the excitability of cochlear nucleus neurons.

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Section: Neuronal Excitabilitymentioning

confidence: 62%

Section: Neuronal Excitabilitymentioning

confidence: 99%

Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus

et al. 2006

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“…In the auditory system, the detection of interaural timing differences in part depends on fast inhibition in a timing circuit (Brand et al 2002), and inhibition may be important for maintaining temporal precision in the monaural pathways that lead to the binaural comparators (Rothman and Manis 2003;Rothman and Young 1996). In many neurons that are not as specialized as those in auditory pathways, the end of strong or synchronous inhibitory input can be signaled by rebound depolarization immediately following hyperpolarization that can cause spiking (Aizenman and Linden 1999;Steriade 2001).…”

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confidence: 99%

Encoding the Timing of Inhibitory Inputs

Manis

2005

Journal of Neurophysiology

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. Many neuronal systems represent information by the timing of individual spikes, and it is generally assumed that spike timing predominantly encodes excitatory inputs. We show here that the timing of inhibition can also be explicitly encoded in spike times using time-dependent and voltage-dependent properties of a rapidly inactivating potassium channel (I KIF ). In vitro recordings in rat dorsal cochlear nucleus show that the effects of inhibition on spike timing can long outlast the duration of the inhibitory potential and that this depends only on the membrane voltage change during the inhibitory postsynaptic potential. Modeling results show that small neuronal populations with a heterogeneous distribution of I KIF voltage dependence can robustly encode intervals of Ͼ100 ms between inhibition and excitation. Thus neuronal systems can detect and represent the precise timing of inhibition, suggesting the importance of inhibition in information encoding.

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“…Our results on the temperature dependence of the spiking threshold reveal that, for the EPSC stimulus with a given frequency, there is a temperature sensitive range for the neuron, and that this range reduces as the stimulus frequency increases. These imply that there is a physiological temperature range which is beneficial to the information processing in auditory system.The model used in this work is presented by Rothman and Manis (RM) [10] for bushy cells in ventral cochlear nucleus of auditory midbrain based on electrophysiological experiments [19]. It consists of a single electrical compartment with a membrane capacitance (C) connected in parallel with a fast-activating slow-inactivating low-threshold K + current (I LT ), a high-threshold K + current (I HT ), a fast-inactivating TTX-sensitive Na + current (I N a ), a hyperpolarizationactivated cation current (I h ), a leakage current (I lk ), and an excitatory synaptic current (I E ).…”

mentioning

confidence: 99%

“…The model used in this work is presented by Rothman and Manis (RM) [10] for bushy cells in ventral cochlear nucleus of auditory midbrain based on electrophysiological experiments [19]. It consists of a single electrical compartment with a membrane capacitance (C) connected in parallel with a fast-activating slow-inactivating low-threshold K + current (I LT ), a high-threshold K + current (I HT ), a fast-inactivating TTX-sensitive Na + current (I N a ), a hyperpolarizationactivated cation current (I h ), a leakage current (I lk ), and an excitatory synaptic current (I E ).…”

mentioning

confidence: 99%

Influence of temperature on neuronal excitability in cochlear nucleus

2010

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The influence of temperature on neuronal excitability is studied by numerical simulations on the spiking threshold characteristics of bushy cells in cochlear nucleus periodically stimulated by synaptic currents. The results reveal that there is a cut-off frequency for the spiking of bushy cell in a specific temperature environment, corresponding to the existence of a critical temperature for the neuron to respond with real spikes to the synaptic stimulus of a given frequency, due to the finiteness of spike width. An optimal temperature range for neuronal spiking is also found for a specific stimulus frequency, and the temperature range span decreases with increasing stimulus frequency. These findings imply that there is a physiological temperature range which is beneficial for the information processing in auditory system. PACS numbers: 87. 19. Dd, 87. 10. +e, 87. 17. Aa, 87. 19. La Electric excitability has been attracting much attention for decades, for it is the basis of information processing and is essential to coding in neural systems. The excitability of a neuron originates from integrated effect of the kinetics [1], as well as the spatial distribution [2], of ion channels on the cellular membrane in proper environment, and determines the functional properties when responding to external stimulus, such as the frequency sensitivity [3,4] or selectivity [5], interaural time difference (ITD) sensitivity in auditory system [6], etc. Excitability and response properties of a neuron may vary in different environmental conditions of, say, temperature and pH values [7]. Recently, the influence of temperature on the excitability of rat suprachiasmatic nucleus neurons has been investigated experimentally, and the results reveal that there is a temperature-sensitive range for the neuronal activities; this may provide cues to the circadian synchronized rhythmicity [8,9]. Biophysically, temperature may influence the functioning of a neuron through the temperature dependence of various ion channel conductances and time constants of channel activation/inactivation variables [10]; hence changing temperature alters the basic properties of excitable neuron, such as the membrane potential, the input resistance, the shape and amplitude of action potentials, and the propagation of spikes [11,12,13,14]. Up to date, however, there has been little theoretical investigations of the influence of temperature on neuronal excitability in literature.Neuronal excitability can be described by the firing properties, like the spiking threshold of the neuron responding to periodic stimulus [5]. Characteristics of the spiking threshold of excitable neurons have been discussed in several studies [3,5,15,16,17], where the stimuli applied are mostly sinusoidal. More realistically, in fact, the stimulus to a post-synaptic neuron is often described by a current with alpha-function channel conductance [18], which is used in the present study. Comparable with Ref. [5], this work focuses on the effect of temperature on the spiking threshold of a...

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The Roles Potassium Currents Play in Regulating the Electrical Activity of Ventral Cochlear Nucleus Neurons

Cited by 264 publications

References 59 publications

Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus

Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus

Encoding the Timing of Inhibitory Inputs

Influence of temperature on neuronal excitability in cochlear nucleus

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